Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 6/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | MELK | Q14680 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.41 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.41 |
| ▸ | PRKCG | P05129 | 3/20 | 0.41 |
| ▸ | PRKCB | P05771 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6965038 | 0.85 | CYP3A4 (0.44) | MEN1KMT2AKDM4ETDP1ALDH1A1 | |
| SCHEMBL6958223 | 0.79 | P2RX7 (0.42) | MEN1KMT2AMAPTKDM4ETDP1 | |
| SCHEMBL6977470 | 0.77 | CYP3A4 (0.44) | POLBMEN1KMT2AKDM4ETDP1 | |
| SCHEMBL6975024 | 0.76 | CYP19A1 (0.44) | MEN1KMT2AKDM4EALDH1A1MELK | |
| SCHEMBL6963085 | 0.76 | CYP3A4 (0.44) | MEN1KMT2AKDM4ETDP1MELK | |
| SCHEMBL6977825 | 0.76 | KDM4E (0.43) | MEN1KMT2AKDM4EMELKMAPK1 | |
| SCHEMBL6966488 | 0.76 | MEN1 (0.44) | MEN1KMT2AKDM4EALDH1A1MAPK1 | |
| SCHEMBL6962005 | 0.75 | NPY1R (0.43) | MEN1KMT2AKDM4EMELKMAPK1 | |
| SCHEMBL6976355 | 0.75 | NPY1R (0.43) | MEN1KMT2AMAPTKDM4ETDP1 | |
| SCHEMBL6970886 | 0.75 | PRKD3 (0.43) | MEN1KMT2AMAPTKDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0855391-B1 | NOVEL ISOQUINOLINE DERIVATIVES | DAIICHI SEIYAKU CO (JP) | 2003-10-15 | — | — | EP | disclosed |
| US-5959107-A | Isoquinoline derivatives | SNOW BRAND MILK PRODUCTS CO., LTD. (JP) | 1999-09-28 | — | — | US | disclosed |
| EP-0855391-A1 | NOVEL ISOQUINOLINE DERIVATIVES | SNOW BRAND MILK PRODUCTS CO., LTD. (JP) | 1998-07-29 | — | — | EP | disclosed |