Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV6 | Q9H1D0 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 4/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | TRPV5 | Q9NQA5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6964019 | 0.82 | TRPV6 (0.53) | TRPV6OPRM1OPRD1OPRL1PDK2 | |
| SCHEMBL1513500 | 0.80 | SIGMAR1 (0.53) | TRPV6HTR2COPRM1OPRD1OPRL1 | |
| SCHEMBL29980126 | 0.80 | SIGMAR1 (0.53) | TRPV6HTR2COPRM1OPRD1OPRL1 | |
| SCHEMBL8142385 | 0.80 | TRPV6 (0.52) | TRPV6OPRM1OPRD1OPRL1KDM4E | |
| Hydrochloric Acid SCHEMBL3326791 | 0.79 | SIGMAR1 (0.51) | TRPV6HTR2COPRM1OPRD1OPRL1 | |
| SCHEMBL9036683 | 0.76 | OPRL1 (0.45) | TRPV6HTR2COPRM1OPRD1OPRL1 | |
| SCHEMBL7040982 | 0.76 | TRPV6 (0.63) | TRPV6OPRM1OPRD1OPRL1KDM4E | |
| SCHEMBL11793878 | 0.76 | TRPV6 (0.48) | TRPV6HTR2COPRM1OPRD1OPRL1 | |
| SCHEMBL6964017 | 0.73 | TRPV6 (0.41) | TRPV6HTR2CPDK2HDAC4 | |
| SCHEMBL1919333 | 0.72 | HDAC4 (0.57) | TRPV6OPRM1OPRD1OPRL1PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0546583-B1 | Piperazinyl-and piperidinyl-cyclohexanols | BRISTOL MYERS SQUIBB CO (US) | 1996-05-22 | — | — | EP | disclosed |
| US-5478828-A | Anxiolytic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-12-26 | — | — | US | disclosed |
| US-5387593-A | Anxiolytic agents | BRISTON-MYERS SQUIBB (US) | 1995-02-07 | — | — | US | disclosed |
| EP-0546583-A1 | Piperazinyl-and piperidinyl-cyclohexanols | Bristol-Myers Squibb Company (US) | 1993-06-16 | — | — | EP | disclosed |