Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 3/20 | 0.38 |
| ▸ | ACE | P12821 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | RAMP1 | O60894 | 2/20 | 0.31 |
| ▸ | CALCRL | Q16602 | 2/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7619079 | 0.83 | FPR2 (0.35) | FPR2ACEGAAKDM4E | |
| SCHEMBL7510369 | 0.83 | FPR2 (0.35) | FPR2ACEGAAKDM4E | |
| SCHEMBL7619075 | 0.83 | FPR2 (0.35) | FPR2ACEGAAKDM4E | |
| SCHEMBL8506958 | 0.78 | CHRM5 (0.45) | SMN1; SMN2 | |
| SCHEMBL16712520 | 0.73 | ALDH1A1 (0.35) | MAPTLMNAGAAKDM4EALDH1A1 | |
| SCHEMBL3051855 | 0.73 | TSHR (0.50) | GAAKDM4EALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL10371338 | 0.73 | ACE (0.64) | ACELMNASMN1; SMN2 | |
| SCHEMBL789030 | 0.72 | MEN1 (0.36) | FPR2TSHR | |
| SCHEMBL3555476 | 0.71 | CHRM5 (0.54) | THRBMAPTLMNATP53GAA | |
| SCHEMBL4321783 | 0.71 | CHRM5 (0.48) | THRBMAPTLMNATP53GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0849269-B9 | Vinyl pyrrolidine cephalosporins with basic substituents | BASILEA PHARMACEUTICA AG (CH) | 2003-03-05 | — | — | EP | disclosed |
| EP-0849269-B1 | Vinyl pyrrolidine cephalosporins with basic substituents | BASILEA PHARMACEUTICA AG (CH) | 2002-07-10 | — | — | EP | disclosed |
| US-5981519-A | Vinyl-pyrrolidinone cephalosporins | HOFFMAN-LA ROCHE INC. (US) | 1999-11-09 | — | — | US | disclosed |
| EP-0849269-A1 | Vinyl pyrrolidine cephalosporins with basic substituents | F. HOFFMANN-LA ROCHE AG (CH) | 1998-06-24 | — | — | EP | disclosed |