Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 2/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 4/20 | 0.35 |
| ▸ | MMP9 | P14780 | 3/20 | 0.35 |
| ▸ | MMP7 | P09237 | 2/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7510369 | 0.90 | FPR2 (0.35) | CHRM5ADRA2C | |
| SCHEMBL7619075 | 0.90 | FPR2 (0.35) | CHRM5ADRA2C | |
| SCHEMBL7619079 | 0.90 | FPR2 (0.35) | CHRM5ADRA2C | |
| SCHEMBL6964128 | 0.78 | FPR2 (0.38) | SMN1; SMN2 | |
| SCHEMBL4227086 | 0.78 | CHRM5 (0.45) | CHRM5ADRA2CCHRM2CHRM4CHRM1 | |
| SCHEMBL892512 | 0.74 | CHRM5 (0.41) | CHRM5ADRA2CSMN1; SMN2 | |
| SCHEMBL8560638 | 0.73 | MAPT (0.51) | — | |
| SCHEMBL8900108 | 0.73 | MAPT (0.51) | — | |
| SCHEMBL8560636 | 0.73 | MAPT (0.51) | — | |
| SCHEMBL2083375 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5925632-A | BACTERICIDES | HOFFMANN-LA ROCHE INC. (US) | 1999-07-20 | — | — | US | disclosed |
| CN-1176641-A | Derivatives of 3-pyrrolidylidene -2 -one -cephalosporines | HOFFMANN LA ROCHE (CH) | 1998-03-18 | — | — | CN | disclosed |
| EP-0812323-A1 | DERIVATIVES OF 3-PYRROLIDYLIDENE-2-ONE-CEPHALOSPORINES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-12-17 | — | — | EP | disclosed |
| WO-1996026943-A1 | DERIVATIVES OF 3-PYRROLIDYLIDENE-2-ONE-CEPHALOSPORINES | F.HOFFMANN-LA ROCHE AG (CH) | 1996-09-06 | — | — | WO | disclosed |