SCHEMBL6964245

SCHEMBL6964245

CC(=O)Oc1cccc(N2CCNCC2)c1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRB1 P08588 4/20 0.65
HTR1A P08908 3/20 0.55
HTR7 P34969 3/20 0.55
CYP3A4 P08684 2/20 0.55
HTR2C P28335 2/20 0.55
HTR3E A5X5Y0 1/20 0.55
HTR3B O95264 1/20 0.55
TP53 P04637 1/20 0.55
CYP1A2 P05177 1/20 0.55
CYP2D6 P10635 1/20 0.55
THRB P10828 1/20 0.55
CYP2C9 P11712 1/20 0.55
HTR2A P28223 1/20 0.55
SLC6A4 P31645 1/20 0.55
CYP2C19 P33261 1/20 0.55
HTR2B P41595 1/20 0.55
HTT P42858 1/20 0.55
HTR3A P46098 1/20 0.55
HTR6 P50406 1/20 0.55
HTR3D Q70Z44 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27836118 0.84 ADRB1 (0.60) ADRB1HTR1AHTR7CYP3A4HTR2C
SCHEMBL4543250 0.83 ADRB1 (0.62) ADRB1HTR1AHTR3EHTR3BHTR3A
SCHEMBL4928979 0.81 ADRB1 (0.69) ADRB1HTR1AHTR7CYP3A4HTR2C
SCHEMBL7838014 0.79 ADRB1 (1.00) ADRB1HTR1AHTR7CYP3A4HTR2C
SCHEMBL379449 0.79 ADRB1 (1.00) ADRB1HTR1AHTR7CYP3A4HTR2C
SCHEMBL13598425 0.78 CYP3A4 (0.46) CYP3A4HTR3EHTR3BHTTHTR3A
SCHEMBL3453744 0.78 ADRB1 (0.58) ADRB1HTR1AHTR7CYP3A4HTR2C
SCHEMBL28566890 0.78 EPHX1 (0.61) ADRB1CYP1A2CYP2C9CYP2C19FAAH
Hydrochloric Acid SCHEMBL7757785 0.78 ADRB1 (0.97) ADRB1HTR1AHTR7CYP3A4HTR2C
SCHEMBL5669070 0.78 ADRB1 (0.97) ADRB1HTR1AHTR7CYP3A4HTR2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0850222-B1 PIPERAZINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF SAMJIN PHARM CO LTD (KR) 2003-05-28 EP disclosed
US-6028195-A AN ANTITUMOR AGENT WITH VERY LOW TOXICITIES SAMJIN PHARMACEUTICAL CO., LTD. (KR) 2000-02-22 US disclosed
US-5780472-A ANTITUMOR AGENTS SAMJIN PHARMACEUTICAZL CO., LTD. (KR) 1998-07-14 US disclosed
EP-0850222-A1 PIPERAZINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF Samjin Pharmaceutical Co., Ltd. (KR) 1998-07-01 EP disclosed
WO-1998000402-A1 PIPERAZINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF SAMJIN PHARMACEUTICAL CO., LTD. (KR) 1998-01-08 WO disclosed
EP-0749425-A1 NEW PIPERAZINE DERIVATIVES AND METHODS FOR THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME SAMJIN PHARM. CO., LTD. (KR) 1996-12-27 EP disclosed
WO-1996021648-A1 NEW PIPERAZINE DERIVATIVES AND METHODS FOR THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME SAMJIN PHARMACEUTICAL CO., LTD. (KR) 1996-07-18 WO disclosed