Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 14/20 | 0.65 |
| ▸ | MMP1 | P03956 | 10/20 | 0.65 |
| ▸ | MMP2 | P08253 | 3/20 | 0.65 |
| ▸ | MMP9 | P14780 | 2/20 | 0.57 |
| ▸ | MMP8 | P22894 | 2/20 | 0.57 |
| ▸ | TACR1 | P25103 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6964283 | 1.00 | MMP3 (0.65) | MMP3MMP1MMP2MMP9MMP8 | |
| SCHEMBL7357677 | 0.92 | MMP1 (0.68) | MMP3MMP1MMP2MMP9MMP8 | |
| SCHEMBL7357689 | 0.92 | MMP1 (0.68) | MMP3MMP1MMP2MMP9MMP8 | |
| SCHEMBL7357861 | 0.92 | MMP3 (0.62) | MMP3MMP1MMP2MMP9MMP8 | |
| SCHEMBL7357865 | 0.92 | MMP3 (0.62) | MMP3MMP1MMP2MMP9MMP8 | |
| SCHEMBL7361337 | 0.91 | MMP3 (0.64) | MMP3MMP1MMP2MMP9MMP8 | |
| SCHEMBL7361333 | 0.91 | MMP3 (0.64) | MMP3MMP1MMP2MMP9MMP8 | |
| SCHEMBL7358539 | 0.90 | MMP3 (0.63) | MMP3MMP1MMP2MMP9MMP8 | |
| SCHEMBL6968594 | 0.90 | MMP3 (0.71) | MMP3MMP1MMP2MMP9MMP8 | |
| SCHEMBL6962504 | 0.90 | MMP3 (0.55) | MMP3MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021424-B1 | THIADIAZOLE AMIDE MMP INHIBITORS | UPJOHN CO (US) | 2003-02-26 | — | — | EP | claimed |
| EP-1021424-A1 | THIADIAZOLE AMIDE MMP INHIBITORS | PHARMACIA & UPJOHN COMPANY (US) | 2000-07-26 | — | — | EP | claimed |
| WO-1997048688-A1 | THIADIAZOLE AMIDE MMP INHIBITORS | PHARMACIA & UPJOHN COMPANY (US) | 1997-12-24 | — | — | WO | claimed |
| EP-1021424-B1 | THIADIAZOLE AMIDE MMP INHIBITORS | UPJOHN CO (US) | 2003-02-26 | — | — | EP | disclosed |
| EP-1021424-A1 | THIADIAZOLE AMIDE MMP INHIBITORS | PHARMACIA & UPJOHN COMPANY (US) | 2000-07-26 | — | — | EP | disclosed |
| WO-1998025949-A1 | SUBSTITUTED 5-AMINO-1,3,4-THIADIAZOLE-2-THIONES | PROSCRIPT, INC. (US) | 1998-06-18 | — | — | WO | disclosed |
| WO-1997048688-A1 | THIADIAZOLE AMIDE MMP INHIBITORS | PHARMACIA & UPJOHN COMPANY (US) | 1997-12-24 | — | — | WO | disclosed |