SCHEMBL7357677

SCHEMBL7357677

CC(NC(=O)C(Cc1ccccc1)NC(=O)OCc1ccccc1)C(=O)Nc1n[nH]c(=S)s1

nearest known ligand 0.68

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
MMP1 P03956 14/20 0.68
MMP2 P08253 12/20 0.68
MMP8 P22894 11/20 0.68
MMP9 P14780 10/20 0.68
MMP3 P08254 9/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7357689 1.00 MMP1 (0.68) MMP1MMP2MMP8MMP9MMP3
SCHEMBL6964283 0.92 MMP3 (0.65) MMP1MMP2MMP8MMP9MMP3
SCHEMBL6964276 0.92 MMP3 (0.65) MMP1MMP2MMP8MMP9MMP3
SCHEMBL7361337 0.91 MMP3 (0.64) MMP1MMP2MMP8MMP9MMP3
SCHEMBL7361333 0.91 MMP3 (0.64) MMP1MMP2MMP8MMP9MMP3
SCHEMBL7357861 0.90 MMP3 (0.62) MMP1MMP2MMP8MMP9MMP3
SCHEMBL7357865 0.90 MMP3 (0.62) MMP1MMP2MMP8MMP9MMP3
SCHEMBL7426200 0.87 MMP3 (0.59) MMP1MMP2MMP8MMP9MMP3
SCHEMBL7423329 0.86 MMP1 (0.59) MMP1MMP2MMP8MMP9MMP3
SCHEMBL7363698 0.86 MMP3 (0.57) MMP1MMP2MMP8MMP9MMP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0845002-A2 AMINO ACID AMIDES OF 5-AMINO-1,3,4-THIADIAZONES AND THEIR USE AS INHIBITORS FOR MATRIX METALLOPROTEINASES PROSCRIPT, INC. (US) 1998-06-03 EP disclosed
WO-1996040745-A2 AMINO ACID AMIDES OF 5-AMINO-1,3,4-THIADIAZONES AND THEIR USE AS INHIBITORS FOR MATRIX METALLOPROTEINASES PROSCRIPT, INC. (US) 1996-12-19 WO disclosed