Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.36 |
| ▸ | DPP4 | P27487 | 2/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4595765 | 0.86 | DPP4 (0.48) | RAB9AHSD11B1JAK2JAK1GAA | |
| SCHEMBL3717661 | 0.84 | RAB9A (0.43) | RAB9AHSD11B1JAK2JAK1GAA | |
| SCHEMBL1693841 | 0.84 | RAB9A (0.43) | RAB9AHSD11B1JAK2JAK1GAA | |
| SCHEMBL24131326 | 0.83 | RAB9A (0.48) | RAB9AHSD11B1JAK2JAK1GAA | |
| SCHEMBL5967869 | 0.82 | RAB9A (0.43) | RAB9AHSD11B1JAK2JAK1GAA | |
| SCHEMBL794087 | 0.82 | RAB9A (0.50) | RAB9AHSD11B1JAK2JAK1GAA | |
| SCHEMBL3683788 | 0.81 | HSD11B1 (0.42) | RAB9AHSD11B1JAK2JAK1GAA | |
| SCHEMBL1693309 | 0.81 | RAB9A (0.43) | RAB9AHSD11B1JAK2JAK1GAA | |
| SCHEMBL6420173 | 0.80 | RAB9A (0.52) | RAB9AHSD11B1JAK2JAK1GAA | |
| SCHEMBL8262844 | 0.79 | RAB9A (0.50) | RAB9AHSD11B1GAAPOLBGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1286978-A1 | CYCLOHEXYL DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LTD. (GB) | 2003-03-05 | — | — | EP | disclosed |
| WO-2001087866-A1 | CYCLOHEXYL DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LIMITED (GB) | 2001-11-22 | — | — | WO | disclosed |