Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 11/20 | 0.44 |
| ▸ | PTPRC | P08575 | 1/20 | 0.41 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | AGXT | P21549 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL161509 | 0.85 | PTPRC (0.45) | PTPRCPTPN6PTPN11PTPN22DYRK1A | |
| SCHEMBL13742552 | 0.82 | DYRK1A (0.48) | DYRK1ASLC6A2CA12CA2 | |
| SCHEMBL22389400 | 0.78 | CA12 (0.42) | KIF11CASP3SLC6A2CA12CA2 | |
| SCHEMBL13472079 | 0.77 | CA12 (0.45) | DYRK1ACA12CA2 | |
| SCHEMBL26548146 | 0.76 | KIF11 (0.58) | KIF11AGXTSLC6A2P2RY14MAOB | |
| SCHEMBL26548524 | 0.76 | KIF11 (0.58) | KIF11AGXTSLC6A2P2RY14MAOB | |
| SCHEMBL23555372 | 0.76 | CA2 (0.49) | DYRK1ACA12CA2 | |
| SCHEMBL8338224 | 0.76 | CA2 (0.49) | DYRK1ACA12CA2 | |
| SCHEMBL26548665 | 0.74 | KIF11 (0.56) | KIF11AGXTSLC6A2P2RY14MAOB | |
| SCHEMBL26549008 | 0.74 | KIF11 (0.56) | KIF11AGXTSLC6A2P2RY14MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421848-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | Janssen Pharmaceutica N.V. (BE) | 2012-02-29 | — | — | EP | claimed |
| WO-2010124119-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | WO | claimed |