Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 13/20 | 0.57 |
| ▸ | HTR1A | P08908 | 3/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.50 |
| ▸ | DRD2 | P14416 | 3/20 | 0.49 |
| ▸ | HTR7 | P34969 | 3/20 | 0.49 |
| ▸ | HTR6 | P50406 | 3/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6966928 | 1.00 | SIGMAR1 (0.57) | SIGMAR1HTR1ASLC6A4DRD2HTR7 | |
| SCHEMBL5527597 | 0.90 | CYP2D6 (0.52) | SLC6A4 | |
| SCHEMBL6962409 | 0.88 | CYP2D6 (0.48) | SIGMAR1SLC6A4 | |
| SCHEMBL6961404 | 0.88 | CYP2D6 (0.48) | HTR1ASLC6A4DRD2HTR7HTR6 | |
| SCHEMBL6966799 | 0.88 | SIGMAR1 (0.56) | SIGMAR1HTR1ASLC6A4DRD2HTR7 | |
| SCHEMBL6966376 | 0.86 | CCR2 (0.47) | SLC6A4 | |
| SCHEMBL6964648 | 0.85 | SIGMAR1 (0.69) | SIGMAR1 | |
| SCHEMBL9677377 | 0.82 | SIGMAR1 (0.71) | SIGMAR1 | |
| SCHEMBL6966093 | 0.82 | SIGMAR1 (0.70) | SIGMAR1 | |
| SCHEMBL6964820 | 0.79 | HTR1A (0.61) | SIGMAR1HTR1ADRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0964863-B1 | OXAZOLIDINES AS 5-HT2A-ANTAGONISTS | MERCK PATENT GMBH (DE) | 2003-05-21 | — | — | EP | disclosed |
| US-6462056-B1 | SUCH AS 3-(4-CHLOROPHENYL)-5-(4-(3-INDOLYL)-1-PIPERIDINYL-METHYL)OXAZOLIDIN-2-ONE; 5-HT2A ANTAGONISTS WITH 5-HT REUPTAKE INHIBITING, ANTIDEPRESSANT OR ANXIOLYTIC EFFECT | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2002-10-08 | — | — | US | disclosed |
| EP-0964863-A1 | OXAZOLIDINES AS 5-HT2A-ANTAGONISTS | MERCK PATENT GmbH (DE) | 1999-12-22 | — | — | EP | disclosed |
| WO-1998038189-A1 | OXAZOLIDINES AS 5-HT2A-ANTAGONISTS | MERCK PATENT GMBH (DE) | 1998-09-03 | — | — | WO | disclosed |