⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5755296 | 0.81 | — | — | |
| SCHEMBL11793080 | 0.78 | TRPA1 (0.34) | — | |
| SCHEMBL533342 | 0.75 | — | — | |
| SCHEMBL316215 | 0.75 | — | — | |
| SCHEMBL4586910 | 0.75 | — | — | |
| SCHEMBL95729 | 0.75 | — | — | |
| SCHEMBL353016 | 0.75 | — | — | |
| SCHEMBL27729555 | 0.73 | HDAC4 (0.32) | — | |
| SCHEMBL2218563 | 0.73 | SLC6A2 (0.44) | — | |
| SCHEMBL27780437 | 0.73 | TRPA1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116444398-B | Preparation method of ketoprofen intermediate formula III | 浙江瑞博制药有限公司 | 2024-06-07 | — | — | CN | disclosed |
| CN-116554017-A | Three-step preparation method of ketoprofen general formula compound | 浙江瑞博制药有限公司 | 2023-08-08 | — | — | CN | disclosed |
| CN-116444361-A | Six-step preparation method of ketoprofen general formula compound | 浙江瑞博制药有限公司 | 2023-07-18 | — | — | CN | disclosed |
| CN-116444398-A | Preparation method of ketoprofen intermediate formula III | 浙江瑞博制药有限公司 | 2023-07-18 | — | — | CN | disclosed |
| CN-109651155-B | Ketone ibuprofen intermediate and preparation method and application thereof | 浙江瑞博制药有限公司 | 2023-04-11 | — | — | CN | disclosed |
| CN-110857269-A | Ketone ibuprofen intermediate and preparation method and application thereof | 江苏瑞科医药科技有限公司 | 2020-03-03 | — | — | CN | disclosed |
| EP-1329160-A2 | 4-ACYLAMINOPYRAZOLE DERIVATIVES | Sankyo Company, Limited (JP) | 2003-07-23 | — | — | EP | disclosed |
| EP-0609058-B1 | Hexahydronaphthalene ester derivatives, their preparation and their therapeutic uses | SANKYO CO (JP) | 1998-12-09 | — | — | EP | disclosed |
| US-5792840-A | SUBSTITUTED GLUCOPYRANOSYL PHOSPHATES | SANKYO COMPANY, LIMITED (JP) | 1998-08-11 | — | — | US | disclosed |
| US-5629406-A | AMINO ACID DERIVATIVES | SANKYO COMPANY, LIMITED (JP) | 1997-05-13 | — | — | US | disclosed |
| EP-0437016-B1 | Lipid A analogues having immunoactivating and anti-tumour activity | SANKYO CO (JP) | 1996-05-01 | — | — | EP | disclosed |
| US-5491167-A | INHIBITORS OF CHOLESTEROL BIOSYNTHESIS | SANKYO COMPANY, LIMITED (JP) | 1996-02-13 | — | — | US | disclosed |
| EP-0609058-A2 | Hexahydronaphthalene ester derivatives, their preparation and their therapeutic uses | SANKYO COMPANY LIMITED (JP) | 1994-08-03 | — | — | EP | disclosed |
| EP-0587311-A1 | Peptides capable of inhibiting the activity of HIV protease, their preparation and their therapeutic use | SANKYO COMPANY LIMITED (JP) | 1994-03-16 | — | — | EP | disclosed |
| EP-0583971-A1 | Piperidine derivatives | SANKYO COMPANY LIMITED (JP) | 1994-02-23 | — | — | EP | disclosed |
| EP-0498680-A1 | New beta-amino-alpha-hydroxycarboxylic acids and their use | Sankyo Company Limited (JP) | 1992-08-12 | — | — | EP | disclosed |
| EP-0437016-A2 | Lipid A analogues having immunoactivating and anti-tumour activity | Sankyo Company Limited (JP) | 1991-07-17 | — | — | EP | disclosed |