Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | MRE11 | P49959 | 1/20 | 0.32 |
| ▸ | PTGES | O14684 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 2/20 | 0.31 |
| ▸ | IDH1 | O75874 | 2/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6960215 | 0.88 | GAA (0.36) | PTGDR2GAAMEN1KMT2ADHFR | |
| SCHEMBL7310660 | 0.82 | DHFR (0.33) | DHFR | |
| SCHEMBL7679979 | 0.81 | DHFR (0.34) | GAAMEN1KMT2ADHFRNPC1 | |
| SCHEMBL6971919 | 0.80 | DHFR (0.36) | GAAMEN1KMT2ADHFRNPC1 | |
| SCHEMBL8324863 | 0.79 | DHFR (0.33) | DHFR | |
| SCHEMBL6972804 | 0.74 | DHFR (0.38) | GAAMEN1KMT2ADHFRNPC1 | |
| SCHEMBL6960025 | 0.74 | GRM5 (0.34) | PTGDR2MEN1KMT2ADHFRERN1 | |
| SCHEMBL7686120 | 0.72 | GAA (0.34) | GAAMEN1KMT2ADHFRMRE11 | |
| SCHEMBL7733912 | 0.70 | NPC1 (0.31) | NPC1RAB9A | |
| SCHEMBL7735172 | 0.69 | SMN1; SMN2 (0.59) | GAAMEN1KMT2ADHFRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0785927-B1 | NOVEL BENZOXAZOLES | EURO CELTIQUE SA (LU) | 2003-08-27 | — | — | EP | claimed |
| EP-1160247-A1 | 6,5-Fused aromatic ring systems having enhanced phosphodiesterae IV inhibitory activity | Euro-Celtique S.A. (LU) | 2001-12-05 | — | — | EP | claimed |
| EP-0785927-A4 | NOVEL BENZOXAZOLES | EURO CELTIQUE SA (LU) | 1997-12-29 | — | — | EP | claimed |
| US-5665737-A | PHOSPHODIESTERASE INHIBITORS | EURO-CELTIQUE, S.A. (LU) | 1997-09-09 | — | — | US | claimed |
| EP-0785927-A1 | NOVEL BENZOXAZOLES | Euroceltique S.A. (LU) | 1997-07-30 | — | — | EP | claimed |
| WO-1996011917-A1 | NOVEL BENZOXAZOLES | EURO-CELTIQUE, S.A. (LU) | 1996-04-25 | — | — | WO | claimed |
| EP-2193808-A1 | Synergistic combination | Nycomed GmbH (DE) | 2010-06-09 | — | — | EP | disclosed |
| EP-1849468-A2 | Pharmaceutical composition of a pde4 or a pde3/4 inhibitor and a histamine receptor antagonist | Nycomed GmbH (DE) | 2007-10-31 | — | — | EP | disclosed |
| WO-2004047817-A1 | PDE4 AND PDE3/4 INHIBITORS FOR USE IN THE TREATMENT OF CACHEXIA | ALTANA PHARMA AG (DE) | 2004-06-10 | — | — | WO | disclosed |
| EP-0785927-B1 | NOVEL BENZOXAZOLES | EURO CELTIQUE SA (LU) | 2003-08-27 | — | — | EP | disclosed |
| WO-2003024488-A2 | COMBINATION OF A PDE INHIBITOR AND A LEUKOTRIENE RECEPTOR ANTAGONIST | ALTANA PHARMA AG (DE) | 2003-03-27 | — | — | WO | disclosed |
| US-6372770-B1 | TREATING A MAMMAL SUFFERING FROM A DISEASE STATE SELECTED FROM THE GROUP CONSISTING OF ASTHMA, ALLERGIES, INFLAMMATION, DEPRESSION, DEMENTIA, ATOPIC DISEASES, RHINITIS AND DISEASE STATES ASSOCIATED WITH ABNORMALLY HIGH PHYSIOLOGICAL LEVELS OF | EURO-CELTIQUE, S.A. | 2002-04-16 | — | — | US | disclosed |
| US-6365606-B1 | TREATMENT OF DISEASES WITH ABNORMALLY HIGH PHYSIOLOGICAL LEVELS OF CYTOKINES; SIDE EFFECT REDUCTION; ISOINDOLES; BRONCHODILATOR; ANTI-INFLAMMATORY AGENT | EURO-CELTIQUE, S.A. (LU) | 2002-04-02 | — | — | US | disclosed |
| EP-1160247-A1 | 6,5-Fused aromatic ring systems having enhanced phosphodiesterae IV inhibitory activity | Euro-Celtique S.A. (LU) | 2001-12-05 | — | — | EP | disclosed |
| JP-2001316314-A | 6,5-UNITED AROMATIC RING SYSTEM HAVING POTENTIATED PHOSPHODIESTERASE IV INHIBITING ACTIVITY | EURO CELTIQUE SA | 2001-11-13 | — | — | JP | disclosed |
| US-6075016-A | 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity | EURO-CELTIQUE S.A. (LU) | 2000-06-13 | — | — | US | disclosed |
| EP-0785927-A4 | NOVEL BENZOXAZOLES | EURO CELTIQUE SA (LU) | 1997-12-29 | — | — | EP | disclosed |
| US-5665737-A | PHOSPHODIESTERASE INHIBITORS | EURO-CELTIQUE, S.A. (LU) | 1997-09-09 | — | — | US | disclosed |
| EP-0785927-A1 | NOVEL BENZOXAZOLES | Euroceltique S.A. (LU) | 1997-07-30 | — | — | EP | disclosed |
| WO-1996011917-A1 | NOVEL BENZOXAZOLES | EURO-CELTIQUE, S.A. (LU) | 1996-04-25 | — | — | WO | disclosed |