Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.46 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 7/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6965120 | 1.00 | ALOX5 (0.52) | ALOX5KMT2AALDH1A1KDM4ETLR8 | |
| SCHEMBL6963715 | 0.77 | ALDH1A1 (0.50) | KMT2AALDH1A1KDM4ETLR8MEN1 | |
| SCHEMBL6963711 | 0.77 | ALDH1A1 (0.50) | KMT2AALDH1A1KDM4ETLR8MEN1 | |
| SCHEMBL6958102 | 0.76 | ALOX5 (0.65) | ALOX5KMT2AALDH1A1KDM4EHCAR2 | |
| SCHEMBL6958095 | 0.76 | ALOX5 (0.65) | ALOX5KMT2AALDH1A1KDM4EHCAR2 | |
| SCHEMBL13359392 | 0.75 | ALOX5 (0.53) | ALOX5KMT2AALDH1A1KDM4EHCAR2 | |
| SCHEMBL15722176 | 0.74 | ALDH1A1 (0.51) | ALOX5KMT2AALDH1A1KDM4EHCAR2 | |
| SCHEMBL372264 | 0.74 | ALDH1A1 (0.62) | ALOX5KMT2AALDH1A1KDM4EGSK3B | |
| SCHEMBL5904736 | 0.73 | KMT2A (0.60) | ALOX5KMT2AALDH1A1KDM4EGSK3B | |
| SCHEMBL5904733 | 0.73 | KMT2A (0.60) | ALOX5KMT2AALDH1A1KDM4EGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0974584-B1 | FUSED RING COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-01-15 | — | — | EP | disclosed |
| US-6420375-B1 | ANTITUMOR | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-0974584-A1 | FUSED RING COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2000-01-26 | — | — | EP | disclosed |