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SCHEMBL6965286

SCHEMBL6965286

Cc1cc(C2CCN(S(=O)(=O)C(C)(C)C(=O)NO)CC2)ccc1-c1cccc(OCCO)n1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ MMP3 P08254 9/20 1.00
▸ MMP2 P08253 7/20 1.00
▸ MMP1 P03956 2/20 1.00
▸ MMP9 P14780 2/20 1.00
▸ MMP14 P50281 2/20 1.00
▸ FFAR4 Q5NUL3 2/20 0.34
▸ HSD11B1 P28845 1/20 0.33
▸ GUCY1A1 Q02108 3/20 0.33
▸ GUCY1B1 Q02153 3/20 0.33
▸ RAF1 P04049 2/20 0.33
▸ JAK2 O60674 1/20 0.32
▸ JAK3 P52333 1/20 0.32
▸ PTK2 Q05397 1/20 0.32
▸ TLR9 Q9NR96 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6960751 0.93 MMP2 (0.87) MMP3MMP2MMP1MMP9MMP14
SCHEMBL6584994 0.92 MMP2 (0.85) MMP3MMP2MMP1MMP9MMP14
SCHEMBL6435723 0.91 MMP2 (0.84) MMP3MMP2MMP1MMP9MMP14
SCHEMBL6972569 0.91 MMP2 (0.84) MMP3MMP2MMP1MMP9MMP14
SCHEMBL6433680 0.90 MMP2 (0.82) MMP3MMP2MMP1MMP9MMP14
SCHEMBL6585851 0.85 MMP3 (1.00) MMP3MMP2MMP1MMP9MMP14
SCHEMBL6435131 0.84 MMP2 (0.72) MMP3MMP2MMP1MMP9MMP14
SCHEMBL6436932 0.83 MMP2 (0.71) MMP3MMP2MMP1MMP9MMP14
SCHEMBL6586527 0.83 MMP2 (0.71) MMP3MMP2MMP1MMP9MMP14
SCHEMBL6588355 0.83 MMP2 (0.70) MMP3MMP2MMP1MMP9MMP14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1181017-B1 METALLOPROTEASE INHIBITORS PFIZER LTD (GB) 2003-04-16 — — EP claimed