Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.30 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6178236 | 0.83 | L3MBTL1 (0.35) | L3MBTL1SLC2A1KDM4ETDP1 | |
| SCHEMBL6180961 | 0.77 | L3MBTL1 (0.34) | L3MBTL1MMP13 | |
| SCHEMBL6177046 | 0.75 | L3MBTL1 (0.32) | L3MBTL1 | |
| SCHEMBL6174342 | 0.70 | ITGB3 (0.45) | L3MBTL1KDM4E | |
| SCHEMBL3711368 | 0.65 | CTSK (0.38) | — | |
| SCHEMBL255184 | 0.63 | CA14 (0.38) | — | |
| SCHEMBL2955454 | 0.63 | TDP1 (0.37) | SLC2A1KDM4ETDP1 | |
| SCHEMBL1624562 | 0.63 | MEN1 (0.50) | L3MBTL1 | |
| SCHEMBL27268544 | 0.62 | CA14 (0.43) | TDP1 | |
| SCHEMBL27268565 | 0.62 | CA14 (0.43) | TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102587-A4 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2003-03-12 | — | — | EP | disclosed |
| US-6458814-B1 | VITRONECTIN RECEPTOR ANTAGONISTS AND ARE USEFUL IN THE TREATMENT OF OSTEOPOROSIS: TREATMENT OF INFLAMMATION, CANCER AND CARDIOVASCULAR DISORDERS, SUCH AS ATHEROSCLEROSIS AND RESTENOSIS, AND DISEASES WHEREIN BONE RESORPTION IS A FACTOR, | SMITHKLINE BEECHAM CORPORATION | 2002-10-01 | — | — | US | disclosed |
| CN-1322133-A | Vitronectin receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 2001-11-14 | — | — | CN | disclosed |
| EP-1102587-A2 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000007544-A2 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-02-17 | — | — | WO | disclosed |