Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 8/20 | 0.44 |
| ▸ | HRH2 | P25021 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 2/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6532387 | 0.87 | HTR6 (0.51) | HTR6ALOX5KDM4EATM | |
| SCHEMBL6529706 | 0.87 | HTR6 (0.51) | HTR6ALOX5KDM4EATM | |
| SCHEMBL6529704 | 0.87 | HTR6 (0.51) | HTR6ALOX5KDM4EATM | |
| SCHEMBL7479507 | 0.81 | KCNH2 (0.44) | HTR6ALOX5RORC | |
| SCHEMBL7482377 | 0.81 | HTR6 (0.48) | HTR6HRH2RORC | |
| SCHEMBL6965222 | 0.80 | HTR6 (0.36) | HTR6ALOX5RORCKDM4EATM | |
| SCHEMBL7491511 | 0.79 | HTR6 (0.53) | HTR6HRH2ALOX5KDM4E | |
| SCHEMBL6965218 | 0.79 | HTR6 (0.36) | HTR6ALOX5RORCKDM4EATM | |
| SCHEMBL6977564 | 0.74 | ESRRG (0.33) | HTR6ALOX5RORCKDM4E | |
| SCHEMBL7491819 | 0.74 | HTR6 (0.43) | HTR6HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1289479-C | As 5-HT1D5-ring indole compounds of receptor ligands | ALLELIX BIOPHARMA (CA) | 2006-12-13 | — | — | CN | disclosed |
| EP-0944595-B1 | 5-CYCLO INDOLE COMPOUNDS AS 5-HT1D RECEPTOR LIGANDS | NPS ALLELIX CORP (CA) | 2003-10-01 | — | — | EP | disclosed |
| CN-1245491-A | 5-cyclo indole compounds as 5-HT receptor ligands | ALLELIX BIOPHARMA (CA) | 2000-02-23 | — | — | CN | disclosed |
| US-5998438-A | SEROTONIN RECEPTOR ANTAGONIST; HEADACHE THERAPY | ALLELIX BIOPHARMACEUTICALS, INC. (CA) | 1999-12-07 | — | — | US | disclosed |
| EP-0944595-A1 | 5-CYCLO INDOLE COMPOUNDS AS 5-HT1D RECEPTOR LIGANDS | Allelix Biopharmaceuticals Inc. (CA) | 1999-09-29 | — | — | EP | disclosed |
| WO-1998023587-A1 | 5-CYCLO INDOLE COMPOUNDS AS 5-HT1D RECEPTOR LIGANDS | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 1998-06-04 | — | — | WO | disclosed |