SCHEMBL6965329

SCHEMBL6965329

CCn1c(COC(C)=O)nc(Sc2cccc(Cl)c2)c1C(C)C

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX12 P18054 1/20 0.41
TP53 P04637 1/20 0.37
RXFP1 Q9HBX9 1/20 0.37
MAPT P10636 3/20 0.36
HPGD P15428 2/20 0.36
MEN1 O00255 1/20 0.36
GAA P10253 1/20 0.36
KMT2A Q03164 1/20 0.36
SLC6A9 P48067 2/20 0.35
PTPN11 Q06124 1/20 0.35
RAB9A P51151 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
KDM4E B2RXH2 1/20 0.34
ALDH1A1 P00352 1/20 0.34
POLB P06746 1/20 0.34
LMNA P02545 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6965465 0.91 ALOX12 (0.41) ALOX12TP53RXFP1MAPTHPGD
SCHEMBL6961401 0.90 CYP1A2 (0.31) ALOX12MAPTCYP1A2CYP3A4CYP2C9
SCHEMBL7086265 0.88 CA2 (0.36) MAPTHPGDMEN1GAAKMT2A
SCHEMBL6964412 0.88 ALOX12 (0.41) ALOX12TP53RXFP1MAPTHPGD
SCHEMBL6957340 0.88 CSNK2A2 (0.38) ALOX12TP53RXFP1MAPTHPGD
SCHEMBL7082595 0.87 CYP1A2 (0.40) TP53RXFP1MAPTMEN1GAA
SCHEMBL6974125 0.85 CYP2C9 (0.39) MAPTHPGDMEN1GAAKMT2A
SCHEMBL7087095 0.84 LMNA (0.38) ALOX12TP53RXFP1MAPTHPGD
SCHEMBL6960600 0.84 ALOX12 (0.36) ALOX12TP53RXFP1MAPTHPGD
SCHEMBL7081639 0.84 ALOX12 (0.38) ALOX12TP53RXFP1MAPTHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786455-B1 IMIDAZOLE DERIVATIVE SHIONOGI & CO (JP) 2003-12-03 EP disclosed
US-6147097-A METHOD FOR TREATING AIDS SHIONOGI & CO., LTD. (JP) 2000-11-14 US disclosed
US-5910506-A IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC SHIONOGI & CO., LTD. (JP) 1999-06-08 US disclosed
EP-0786455-A1 IMIDAZOLE DERIVATIVE SHIONOGI & CO., LTD. (JP) 1997-07-30 EP disclosed