SCHEMBL6965338

SCHEMBL6965338

COC(=O)c1ccc2cc([N+](=O)[O-])ccc2n1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.53
KDM4E B2RXH2 2/20 0.53
GAA P10253 2/20 0.53
MAPT P10636 1/20 0.53
TTR P02766 1/20 0.46
HTR3E A5X5Y0 1/20 0.44
HTR3B O95264 1/20 0.44
CYP1A2 P05177 1/20 0.44
CYP3A4 P08684 1/20 0.44
SLC6A4 P31645 1/20 0.44
CYP2C19 P33261 1/20 0.44
THPO P40225 1/20 0.44
HTR3A P46098 1/20 0.44
HTR3D Q70Z44 1/20 0.44
HTR3C Q8WXA8 1/20 0.44
DYRK1A Q13627 1/20 0.44
POLB P06746 1/20 0.43
LMNA P02545 1/20 0.43
PMP22 Q01453 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30663244 0.90 ALDH1A1 (0.54) ALDH1A1KDM4EGAAMAPTDYRK1A
SCHEMBL29024921 0.82 MAPT (0.60) ALDH1A1MAPTPOLBLMNANPSR1
SCHEMBL8541741 0.82 ALDH1A1 (0.58) ALDH1A1KDM4EGAAMAPTTTR
SCHEMBL28006558 0.81 ALDH1A1 (0.50) ALDH1A1KDM4EGAAMAPTTTR
SCHEMBL2906892 0.80 ALDH1A1 (0.60) ALDH1A1DYRK1APOLBKMT2AMEN1
SCHEMBL8539149 0.79 ALDH1A1 (0.53) ALDH1A1KDM4EGAAMAPTTTR
SCHEMBL1202391 0.79 LCK (0.50) ALDH1A1KDM4EGAAMAPTCYP1A2
SCHEMBL5214685 0.79 ALDH1A1 (0.58) ALDH1A1MAPTPOLBKMT2AMEN1
SCHEMBL5990759 0.79 ALDH1A1 (0.58) ALDH1A1CYP3A4POLBKMT2AMEN1
SCHEMBL2902589 0.78 ALDH1A1 (0.51) ALDH1A1KDM4EGAAMAPTCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114213394-B Synthesis method of N-sugar analysis reagent fluorogenic substrate 上海瀚诺威生物科技有限公司 2022-11-08 CN claimed
CN-114213394-A Synthesis method of N-sugar analysis reagent fluorogenic substrate 上海瀚诺威生物科技有限公司 2022-03-22 CN claimed
CN-114213394-B Synthesis method of N-sugar analysis reagent fluorogenic substrate 上海瀚诺威生物科技有限公司 2022-11-08 CN disclosed
CN-114213394-A Synthesis method of N-sugar analysis reagent fluorogenic substrate 上海瀚诺威生物科技有限公司 2022-03-22 CN disclosed
CN-1142162-C Bicyclic oxazolidinones as antibacterial agents �������Ŷ���Լ��������˾ 2004-03-17 CN disclosed
EP-1181288-B1 BICYCLIC OXAZOLIDINONES AS ANTIBACTERIAL AGENT UPJOHN CO (US) 2003-07-30 EP disclosed
US-20020143009-A1 Novel bicyclic oxazolidinones as antibacterial agents PHARMACIA & UPJOHN 2002-10-03 US disclosed
CN-1353709-A Bicyclic oxazolidinones as antibacterial agents PHARMACIA & UP JOHN CO (US) 2002-06-12 CN disclosed
US-6387896-B1 GRAMNEGATIVE, GRAMPOSITVE BACTERIA PHARMACIA & UPJOHN CO. 2002-05-14 US disclosed
EP-1181288-A1 BICYCLIC OXAZOLIDINONES AS ANTIBACTERIAL AGENT PHARMACIA & UPJOHN COMPANY (US) 2002-02-27 EP disclosed
WO-2000073301-A1 BICYCLIC OXAZOLIDINONES AS ANTIBACTERIAL AGENT PHARMACIA & UPJOHN COMPANY (US) 2000-12-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020143009-A1 Novel bicyclic oxazolidinones as antibacterial agents OXA1L, MRPL21, RPS4Y1 ALDH1A1 1430/4885KDM4E 3964/4885GAA 1690/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.