Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.39 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8540920 | 0.80 | ALDH1A1 (0.43) | ALDH1A1MAPTGAAKDM4EPOLB | |
| SCHEMBL6965338 | 0.79 | ALDH1A1 (0.53) | ALDH1A1MAPTGAAKDM4EPOLB | |
| SCHEMBL8541741 | 0.76 | ALDH1A1 (0.58) | ALDH1A1MAPTGAAKDM4ETTR | |
| SCHEMBL5101748 | 0.75 | CYP3A4 (0.57) | ALDH1A1KDM4EPOLBCYP3A4RAB9A | |
| SCHEMBL8545179 | 0.75 | ALDH1A1 (0.48) | ALDH1A1MAPTGAAKDM4EPOLB | |
| SCHEMBL28006558 | 0.74 | ALDH1A1 (0.50) | ALDH1A1MAPTGAAKDM4EPOLB | |
| SCHEMBL8542694 | 0.73 | MEN1 (0.44) | ALDH1A1MAPTGAAKDM4EPOLB | |
| SCHEMBL9700739 | 0.73 | KMT2A (0.55) | ALDH1A1MAPTKDM4EPOLBCYP3A4 | |
| SCHEMBL10492784 | 0.73 | CYP3A4 (0.50) | ALDH1A1MAPTGAANPSR1CYP3A4 | |
| SCHEMBL11758391 | 0.73 | CYP3A4 (0.50) | ALDH1A1POLBCYP3A4KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0581500-B1 | Antibiotic carbapenem compounds | ZENECA LTD (GB) | 1998-09-09 | — | — | EP | disclosed |
| US-5441949-A | Carbapenem antibiotic compounds | ZENECA LIMITED (GB) | 1995-08-15 | — | — | US | disclosed |
| EP-0581500-A1 | Antibiotic carbapenem compounds | ZENECA LIMITED (GB) | 1994-02-02 | — | — | EP | disclosed |