Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.67 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.67 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.59 |
| ▸ | HEXA | P06865 | 1/20 | 0.58 |
| ▸ | HEXB | P07686 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | PARK7 | Q99497 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | CASP3 | P42574 | 1/20 | 0.56 |
| ▸ | CMA1 | P23946 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 4/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8801774 | 0.93 | NR1H2 (0.62) | NR1H2NR1H3SIGMAR1HEXAHEXB | |
| SCHEMBL12431372 | 0.90 | HEXA (0.60) | NR1H2NR1H3SIGMAR1HEXAHEXB | |
| SCHEMBL18669155 | 0.86 | KMT2A (0.75) | NR1H2NR1H3SIGMAR1ALDH1A1HPGD | |
| SCHEMBL6949731 | 0.85 | PARK7 (0.70) | NR1H2NR1H3ALDH1A1HPGDKDM4E | |
| SCHEMBL7886525 | 0.85 | RAB9A (0.57) | NR1H2NR1H3ALDH1A1HPGDKDM4E | |
| SCHEMBL14524630 | 0.85 | HEXA (0.56) | NR1H2NR1H3SIGMAR1HEXAHEXB | |
| SCHEMBL30758623 | 0.84 | RAB9A (0.68) | NR1H3ALDH1A1CASP3RAB9AGAA | |
| SCHEMBL29168851 | 0.84 | RAB9A (0.68) | NR1H3ALDH1A1CASP3RAB9AGAA | |
| SCHEMBL4172046 | 0.82 | NR1H3 (0.55) | NR1H2NR1H3SIGMAR1HEXAHEXB | |
| SCHEMBL4172051 | 0.82 | NR1H3 (0.55) | NR1H2NR1H3SIGMAR1HEXAHEXB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017049409-A1 | COMPOSITIONS FOR PROMOTING READTHROUGH OF PREMATURE TERMINATION CODONS, AND METHODS OF USING THE SAME | THE CENTRE FOR DRUG RESEARCH AND DEVELOPMENT (CA) | 2017-03-30 | — | — | WO | disclosed |
| WO-2017049409-A1 | COMPOSITIONS FOR PROMOTING READTHROUGH OF PREMATURE TERMINATION CODONS, AND METHODS OF USING THE SAME | THE CENTRE FOR DRUG RESEARCH AND DEVELOPMENT (CA) | 2017-03-30 | — | — | WO | disclosed |
| EP-1064262-B1 | SUBSTITUTED ISOINDOLONES AND THEIR USE AS CYCLIC GMP MODULATORS IN MEDICAMENTS | AVENTIS PHARMA GMBH (DE) | 2003-02-12 | — | — | EP | disclosed |
| US-6344468-B1 | CARDIOVASCULAR DISEASES SUCH AS HYPERTENSION, ANGINA PECTORIS, CARDIAC INSUFFICIENCY, THROMBOSES OR ATHEROSCLEROSIS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-02-05 | — | — | US | disclosed |
| US-6172091-B1 | METABOLIC CALCIUM IMBALANCE AND OSTEOPOROSIS | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2001-01-09 | — | — | US | disclosed |
| EP-1064262-A1 | SUBSTITUTED ISOINDOLONES AND THEIR USE AS CYCLIC GMP MODULATORS IN MEDICAMENTS | Aventis Pharma Deutschland GmbH (DE) | 2001-01-03 | — | — | EP | disclosed |
| WO-1999042444-A1 | SUBSTITUTED ISOINDOLONES AND THEIR USE AS CYCLIC GMP MODULATORS IN MEDICAMENTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 1999-08-26 | — | — | WO | disclosed |