Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TOP2A | P11388 | 2/20 | 0.36 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6967031 | 0.89 | CYP1A2 (0.44) | TOP2ATOP2BALDH1A1POLBTDP1 | |
| SCHEMBL6969756 | 0.87 | ALOX12 (0.40) | LMNAALDH1A1POLBCYP1A2CYP2C9 | |
| SCHEMBL7084947 | 0.87 | EPHX1 (0.37) | LMNAEPHX1ALDH1A1L3MBTL1MAPT | |
| SCHEMBL6971287 | 0.86 | ALDH1A1 (0.36) | LMNATOP2ATOP2BEPHX1ALDH1A1 | |
| SCHEMBL6969923 | 0.85 | LMNA (0.36) | LMNAEPHX1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6975484 | 0.84 | LMNA (0.36) | LMNA | |
| SCHEMBL7082337 | 0.84 | LMNA (0.36) | LMNACYP1A2CYP2C9CYP2C19L3MBTL1 | |
| SCHEMBL6974900 | 0.84 | LMNA (0.42) | LMNAALDH1A1POLBTDP1CYP2C9 | |
| SCHEMBL6969941 | 0.81 | CYP1A2 (0.39) | LMNATOP2ATOP2BEPHX1CYP1A2 | |
| SCHEMBL6973086 | 0.81 | PIM1 (0.36) | LMNATOP2ATOP2BALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |