Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 6/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | PARP1 | P09874 | 4/20 | 0.50 |
| ▸ | TNKS | O95271 | 1/20 | 0.50 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | KDM4A | O75164 | 1/20 | 0.49 |
| ▸ | KDM5A | P29375 | 1/20 | 0.49 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.49 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.49 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15958954 | 0.89 | PARP1 (0.62) | DHODHALDH1A1KDM4ERAB9AHPGD | |
| SCHEMBL6840234 | 0.89 | ALDH1A1 (0.52) | DHODHALDH1A1KDM4ERAB9ANPC1 | |
| SCHEMBL6840235 | 0.88 | TNKS (0.54) | DHODHALDH1A1KDM4ERAB9ANPC1 | |
| SCHEMBL6840181 | 0.88 | TNKS (0.54) | DHODHALDH1A1KDM4ERAB9AHPGD | |
| SCHEMBL3579908 | 0.88 | PARP1 (0.61) | DHODHALDH1A1KDM4ERAB9ANPC1 | |
| SCHEMBL15958955 | 0.88 | PARP1 (0.47) | DHODHALDH1A1KDM4ERAB9ANPC1 | |
| SCHEMBL505009 | 0.87 | DHODH (0.65) | DHODH | |
| SCHEMBL505273 | 0.87 | PARP1 (0.52) | DHODHALDH1A1KDM4EHPGDPARP1 | |
| SCHEMBL505582 | 0.86 | DHODH (0.64) | DHODHALDH1A1KDM4EHPGDPARP1 | |
| SCHEMBL6840289 | 0.86 | PIN1 (0.56) | DHODHALDH1A1KDM4ERAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 122 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20010024833-A1 | Methods for the solid phase synthesis of combinatorial libraries of benzimidazol, benzoxazoles, benzothiazoles, and derivatives thereof | LABORDE EDGARDO (US) | 2001-09-27 | — | — | US | claimed |
| US-6251689-B1 | BINDING TO RESIN; OXIDATION | TELIK, INC. | 2001-06-26 | — | — | US | claimed |
| US-11339130-B1 | Calpain modulators and therapeutic uses thereof | BLADE THERAPEUTICS, INC. (US) | 2022-05-24 | — | — | US | disclosed |
| CN-109096204-B | Dye compound and preparation method and application thereof | 徐州合谷生命科技有限公司 | 2021-09-17 | — | — | CN | disclosed |
| US-10934261-B2 | Calpain modulators and therapeutic uses thereof | BLADE THERAPEUTICS, INC. (US) | 2021-03-02 | — | — | US | disclosed |
| US-10894776-B2 | — | — | 2021-01-19 | — | — | US | disclosed |
| EP-2959918-B1 | ANTI-MALIGNANT TUMOR AGENT COMPOSITION | J PHARMA CO LTD (JP) | 2019-05-22 | — | — | EP | disclosed |
| US-10172835-B2 | Anticancer agent composition | J-PHARMA CO., LTD. (JP) | 2019-01-08 | — | — | US | disclosed |
| WO-2018064119-A1 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF | BLADE THERAPEUTICS, INC. (US) | 2018-04-05 | — | — | WO | disclosed |
| US-20160279103-A1 | AN ANTICANCER AGENT COMPOSITION | J-PHARMA CO., LTD. (JP) | 2016-09-29 | — | — | US | disclosed |
| EP-2959918-A1 | ANTI-MALIGNANT TUMOR AGENT COMPOSITION | J-Pharma Co., Ltd. (JP) | 2015-12-30 | — | — | EP | disclosed |
| US-6310082-B1 | PHARMACEUTICAL COMPOSITION COMPRISING EFFECTIVE POLY(ADP-RIBOSE)POLYMERASE ENZYME INHIBITING AMOUNT OF BENZIMIDAZOLE COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT AND/OR PRO-DRUG FORM THEREOF, WITH ACCEPTABLE CARRIER | NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) | 2001-10-30 | — | — | US | disclosed |
| US-20010024833-A1 | Methods for the solid phase synthesis of combinatorial libraries of benzimidazol, benzoxazoles, benzothiazoles, and derivatives thereof | LABORDE EDGARDO (US) | 2001-09-27 | — | — | US | disclosed |
| US-6251689-B1 | BINDING TO RESIN; OXIDATION | TELIK, INC. | 2001-06-26 | — | — | US | disclosed |
| US-6100283-A | PRODRUG PHOSPHATE DERIVATIVE FOR POLY (ADP-RIBOSE) POLYMERASE ENZYME INHIBITOR FOR ADMINISTERING IN CONJUNCTION WITH ANTITUMOR DRUG OR RADIOTHERAPY | NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) | 2000-08-08 | — | — | US | disclosed |
| EP-0936218-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1999-08-18 | — | — | EP | disclosed |
| US-5852046-A | Benzo-fused heterocyclic compounds having a 5-membered ring processes for their preparation their use as medicaments their use as diagnostic agents and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-12-22 | — | — | US | disclosed |
| CN-1195985-A | Benzimidazole compounds | UNIV NEWCASTLE VENTURES LTD (GB) | 1998-10-14 | — | — | CN | disclosed |
| EP-0841924-A1 | BENZIMIDAZOLE COMPOUNDS | NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) | 1998-05-20 | — | — | EP | disclosed |
| WO-1997004771-A1 | BENZIMIDAZOLE COMPOUNDS | NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) | 1997-02-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10934261-B2 | Calpain modulators and therapeutic uses thereof | CAPNS1, CAPN9, CAPN1 | DHODH 4397/4885ALDH1A1 4193/4885KDM4E 3495/4885 |
| US-10894776-B2 | — | CAPNS1, CAPN9, CAPN2 | DHODH 4428/4885ALDH1A1 4421/4885KDM4E 3117/4885 |
| US-20160279103-A1 | AN ANTICANCER AGENT COMPOSITION | TUBB1, TUBA1A, TUBA1C | DHODH 2990/4885ALDH1A1 2612/4885KDM4E 4145/4885 |
| US-20010024833-A1 | Methods for the solid phase synthesis of combinatorial libraries of benzimidazol, benzoxazoles, benzothiazoles, and derivatives thereof | EIF2AK2, CDK15, CDK17 | DHODH 889/4885ALDH1A1 3805/4885KDM4E 2008/4885 |
| US-11339130-B1 | Calpain modulators and therapeutic uses thereof | CAPNS1, CAPN9, CAPN1 | DHODH 4397/4885ALDH1A1 4193/4885KDM4E 3495/4885 |
| US-10172835-B2 | Anticancer agent composition | TOP1, TUBB1, TUBA1A | DHODH 2779/4885ALDH1A1 2554/4885KDM4E 4258/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.