Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | CDC25B | P30305 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.40 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.40 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.39 |
| ▸ | WDR5 | P61964 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7761163 | 0.84 | NR4A1 (0.44) | NR4A1NR4A2NR4A3TDP1CDC25B | |
| SCHEMBL7373916 | 0.77 | ALDH1A1 (0.49) | CDC25BSMN1; SMN2LMNARECQLALDH1A1 | |
| SCHEMBL2831699 | 0.75 | NR4A1 (0.50) | NR4A1NR4A2NR4A3TDP1CDC25B | |
| SCHEMBL11294594 | 0.75 | ALDH1A1 (0.39) | NR4A1NR4A2NR4A3TDP1CDC25B | |
| SCHEMBL22500155 | 0.74 | LMNA (0.39) | NR4A1NR4A2NR4A3TDP1SMN1; SMN2 | |
| SCHEMBL6965317 | 0.73 | ALDH1A1 (0.42) | ALDH1A1SLC1A3SLC1A2SLC1A1HSD17B10 | |
| SCHEMBL9342243 | 0.73 | CYP1A2 (0.45) | TDP1SMN1; SMN2LMNAALDH1A1CYP1A2 | |
| SCHEMBL7761500 | 0.73 | MMP2 (0.47) | CYP1A2HDAC8MMP3 | |
| SCHEMBL8117899 | 0.73 | HDAC8 (0.45) | LMNAALDH1A1KDM4EHDAC8HDAC3 | |
| SCHEMBL7445725 | 0.73 | HDAC3 (0.44) | NR4A1NR4A2NR4A3TDP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729465-B1 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE DAVIS & CO (US) | 2003-01-22 | — | — | EP | disclosed |
| US-6005103-A | TREATMENT OF BACTERIAL AND VIRAL INFECTIONS AND DISEASES, INCLUDING AIDS | WARNER-LAMBERT COMPANY (US) | 1999-12-21 | — | — | US | disclosed |
| US-5808062-A | AIDS THERAPY | WARNER-LAMBERT COMPANY (US) | 1998-09-15 | — | — | US | disclosed |