SCHEMBL6966030

SCHEMBL6966030

Nc1cnc2cc(OCc3ccccc3)ccc2c1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.62
ALOX5 P09917 1/20 0.57
MAOB P27338 6/20 0.54
RAB9A P51151 2/20 0.54
MAPT P10636 2/20 0.54
MAOA P21397 2/20 0.54
GAA P10253 1/20 0.54
SMN1; SMN2 Q16637 1/20 0.54
L3MBTL1 Q9Y468 1/20 0.54
PDGFRB P09619 1/20 0.50
PDGFRA P16234 1/20 0.50
NPC1 O15118 2/20 0.49
NPSR1 Q6W5P4 1/20 0.47
DHFR P00374 1/20 0.47
CA12 O43570 2/20 0.46
CA1 P00915 2/20 0.46
CA2 P00918 2/20 0.46
CA7 P43166 2/20 0.46
CA9 Q16790 2/20 0.46
MEN1 O00255 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10260596 0.82 CYP3A4 (0.62) CYP3A4ALOX5MAOBRAB9AMAOA
SCHEMBL18571362 0.81 CYP3A4 (0.61) CYP3A4ALOX5MAOBRAB9AMAPT
SCHEMBL18571363 0.80 CYP3A4 (0.59) CYP3A4ALOX5MAOBRAB9AMAOA
SCHEMBL17316167 0.79 HPGDS (0.62) CYP3A4ALOX5MAOBRAB9APDGFRB
SCHEMBL6964309 0.78 MAOB (0.51) CYP3A4MAOBMAOA
SCHEMBL4037273 0.78 CYP3A4 (0.64) CYP3A4ALOX5MAOBRAB9AMAOA
SCHEMBL841728 0.77 CYP3A4 (1.00) CYP3A4ALOX5MAOBRAB9AMAOA
SCHEMBL30125417 0.77 CYP3A4 (1.00) CYP3A4ALOX5MAOBRAB9AMAOA
SCHEMBL6955327 0.77 MAOB (0.57) CYP3A4ALOX5MAOBRAB9AMAPT
SCHEMBL6955801 0.76 MAOB (0.46) CYP3A4MAOBPDGFRBPDGFRAMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0787725-B1 QUINOLINE DERIVATIVE NIPPON CHEMIPHAR CO (JP) 2003-04-23 EP disclosed
CN-1071333-C Quinoline derivative NIPPON CHEMIPHAR CO (JP) 2001-09-19 CN disclosed
CN-1170411-A Quinoline derivative NIPPON CHEMIPHAR CO (JP) 1998-01-14 CN disclosed
US-5693651-A HYPOGLYCEMIC AGENTS NIPPON CHEMIPHAR CO., LTD. (JP) 1997-12-02 US disclosed
EP-0787725-A1 QUINOLINE DERIVATIVE NIPPON CHEMIPHAR CO., LTD. (JP) 1997-08-06 EP disclosed