Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 7/20 | 0.42 |
| ▸ | PPARG | P37231 | 6/20 | 0.42 |
| ▸ | CYSLTR2 | Q9NS75 | 5/20 | 0.38 |
| ▸ | CYSLTR1 | Q9Y271 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6965774 | 0.88 | POLB (0.46) | POLBKMT2AL3MBTL1KIF11 | |
| SCHEMBL6954167 | 0.80 | GABRA1 (0.43) | POLBKMT2A | |
| SCHEMBL6958667 | 0.74 | GRIK1 (0.37) | POLBKMT2A | |
| SCHEMBL10585673 | 0.74 | CA12 (0.50) | PPARAPPARGKMT2AL3MBTL1CES2 | |
| SCHEMBL6955616 | 0.73 | POLB (0.41) | POLBL3MBTL1CA12CA9 | |
| SCHEMBL28340637 | 0.72 | POLB (0.45) | POLBPPARAPPARGKMT2AL3MBTL1 | |
| SCHEMBL8538793 | 0.72 | CETP (0.41) | POLBCYSLTR2CYSLTR1KMT2AL3MBTL1 | |
| SCHEMBL6953465 | 0.72 | TSHR (0.49) | POLBPPARACYSLTR2CYSLTR1KMT2A | |
| SCHEMBL8535828 | 0.72 | BACE1 (0.45) | POLBL3MBTL1 | |
| SCHEMBL943257 | 0.72 | APOBEC3G (0.54) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729465-B1 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE DAVIS & CO (US) | 2003-01-22 | — | — | EP | disclosed |
| US-6005103-A | TREATMENT OF BACTERIAL AND VIRAL INFECTIONS AND DISEASES, INCLUDING AIDS | WARNER-LAMBERT COMPANY (US) | 1999-12-21 | — | — | US | disclosed |
| US-5808062-A | AIDS THERAPY | WARNER-LAMBERT COMPANY (US) | 1998-09-15 | — | — | US | disclosed |