Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 2/20 | 0.36 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6966115 | 0.88 | POLB (0.43) | POLBKMT2AL3MBTL1KIF11 | |
| SCHEMBL6954167 | 0.84 | GABRA1 (0.43) | POLBGABRA1GABRB2KMT2ACYP2D6 | |
| SCHEMBL28340637 | 0.84 | POLB (0.45) | POLBACHEALDH1A1GABRA1GABRB2 | |
| SCHEMBL7373427 | 0.81 | ACHE (0.44) | POLBACHEALDH1A1KMT2ACYP2C9 | |
| SCHEMBL6958667 | 0.78 | GRIK1 (0.37) | POLBKMT2A | |
| SCHEMBL6955616 | 0.77 | POLB (0.41) | POLBL3MBTL1CYP2D6 | |
| SCHEMBL21423238 | 0.76 | ACHE (0.38) | POLBACHEGABRA1GABRB2L3MBTL1 | |
| SCHEMBL6953465 | 0.76 | TSHR (0.49) | POLBALDH1A1KMT2AL3MBTL1KIF11 | |
| SCHEMBL8535828 | 0.76 | BACE1 (0.45) | POLBALDH1A1L3MBTL1CYP2D6CYP2C9 | |
| SCHEMBL13990815 | 0.75 | DRD1 (0.43) | POLBACHEALDH1A1GABRA1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729465-B1 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE DAVIS & CO (US) | 2003-01-22 | — | — | EP | disclosed |
| US-6005103-A | TREATMENT OF BACTERIAL AND VIRAL INFECTIONS AND DISEASES, INCLUDING AIDS | WARNER-LAMBERT COMPANY (US) | 1999-12-21 | — | — | US | disclosed |
| US-5808062-A | AIDS THERAPY | WARNER-LAMBERT COMPANY (US) | 1998-09-15 | — | — | US | disclosed |