Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHPS | P49366 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALPL | P05186 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | EDNRA | P25101 | 5/20 | 0.44 |
| ▸ | EDNRB | P24530 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6972208 | 0.89 | DHPS (0.53) | DHPSEDNRAEDNRB | |
| SCHEMBL6957003 | 0.88 | EDNRA (0.47) | DHPSEDNRAEDNRBKMT2AMEN1 | |
| SCHEMBL6969386 | 0.86 | EDNRA (0.53) | DHPSEDNRAEDNRB | |
| SCHEMBL6964772 | 0.85 | EDNRA (0.63) | DHPSEDNRAEDNRB | |
| SCHEMBL6972015 | 0.84 | DHPS (0.53) | DHPSEDNRAEDNRB | |
| SCHEMBL6959001 | 0.83 | EDNRA (0.62) | DHPSEDNRAEDNRB | |
| SCHEMBL6961198 | 0.82 | EDNRA (0.47) | DHPSEDNRAEDNRB | |
| SCHEMBL6972565 | 0.81 | EDNRA (0.47) | DHPSLMNASMN1; SMN2EDNRAEDNRB | |
| SCHEMBL5035301 | 0.80 | EDNRA (0.66) | EDNRAEDNRB | |
| SCHEMBL6961032 | 0.80 | MAPT (0.44) | DHPSEDNRAEDNRBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799209-B1 | SULFONAMIDES | HOFFMANN LA ROCHE (CH) | 2003-08-06 | — | — | EP | disclosed |
| US-6004965-A | Sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 1999-12-21 | — | — | US | disclosed |
| EP-0799209-A1 | NOVEL SULFONAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-10-08 | — | — | EP | disclosed |
| WO-1996019459-A1 | NOVEL SULFONAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 1996-06-27 | — | — | WO | disclosed |