Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHPS | P49366 | 3/20 | 0.53 |
| ▸ | EDNRA | P25101 | 17/20 | 0.52 |
| ▸ | EDNRB | P24530 | 4/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6969386 | 0.94 | EDNRA (0.53) | DHPSEDNRAEDNRB | |
| SCHEMBL6972208 | 0.93 | DHPS (0.53) | DHPSEDNRAEDNRB | |
| SCHEMBL6957003 | 0.91 | EDNRA (0.47) | DHPSEDNRAEDNRB | |
| SCHEMBL6961198 | 0.90 | EDNRA (0.47) | DHPSEDNRAEDNRB | |
| SCHEMBL6959001 | 0.90 | EDNRA (0.62) | DHPSEDNRAEDNRB | |
| SCHEMBL5499789 | 0.89 | EDNRA (0.63) | DHPSEDNRAEDNRB | |
| SCHEMBL5035301 | 0.89 | EDNRA (0.66) | EDNRAEDNRB | |
| SCHEMBL6972565 | 0.88 | EDNRA (0.47) | DHPSEDNRAEDNRB | |
| SCHEMBL6961032 | 0.85 | MAPT (0.44) | DHPSEDNRAEDNRB | |
| SCHEMBL16900663 | 0.85 | EDNRA (0.70) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799209-B1 | SULFONAMIDES | HOFFMANN LA ROCHE (CH) | 2003-08-06 | — | — | EP | disclosed |
| US-6004965-A | Sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 1999-12-21 | — | — | US | disclosed |
| EP-0799209-A1 | NOVEL SULFONAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-10-08 | — | — | EP | disclosed |
| WO-1996019459-A1 | NOVEL SULFONAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 1996-06-27 | — | — | WO | disclosed |