Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 18/20 | 0.47 |
| ▸ | EDNRB | P24530 | 10/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | DHPS | P49366 | 2/20 | 0.43 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.43 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.43 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6969386 | 0.91 | EDNRA (0.53) | EDNRAEDNRBDHPSABCC3ABCC4 | |
| SCHEMBL6972208 | 0.88 | DHPS (0.53) | EDNRAEDNRBDHPSABCC3ABCC4 | |
| SCHEMBL6957003 | 0.88 | EDNRA (0.47) | EDNRAEDNRBDHPSABCC3ABCC4 | |
| SCHEMBL6972015 | 0.88 | DHPS (0.53) | EDNRAEDNRBDHPS | |
| SCHEMBL7850046 | 0.86 | EDNRA (0.59) | EDNRAEDNRBDHPSABCC3ABCC4 | |
| SCHEMBL6960041 | 0.85 | EDNRA (0.67) | EDNRAEDNRBDHPSABCC3ABCC4 | |
| SCHEMBL6961198 | 0.85 | EDNRA (0.47) | EDNRAEDNRBDHPSABCC3ABCC4 | |
| SCHEMBL6959001 | 0.85 | EDNRA (0.62) | EDNRAEDNRBDHPSABCC3ABCC4 | |
| SCHEMBL7445633 | 0.83 | EDNRA (0.45) | EDNRAEDNRBALDH1A1LMNATSHR | |
| SCHEMBL5035301 | 0.82 | EDNRA (0.66) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799209-B1 | SULFONAMIDES | HOFFMANN LA ROCHE (CH) | 2003-08-06 | — | — | EP | disclosed |
| US-6004965-A | Sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 1999-12-21 | — | — | US | disclosed |