Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPT1B known ✓ | Q92523 | 1/20 | 0.43 |
| ▸ | GCK | P35557 | 1/20 | 0.54 |
| ▸ | GRM5 | P41594 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.49 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | CPT1A | P50416 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | PHGDH | O43175 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL6966579 | 1.00 | GCK (0.54) | GCKGRM5MAPK1MAPKAPK2MAP2K1 | |
| Hydrochloric Acid SCHEMBL6975254 | 0.83 | NPC1 (0.58) | MAPK1MAPKAPK2MAP2K1ADORA3NPC1 | |
| Fumaric Acid SCHEMBL6969916 | 0.83 | LMNA (0.59) | MAPK1MAPKAPK2MAP2K1TLR7NPC1 | |
| Maleic Acid SCHEMBL6969903 | 0.83 | LMNA (0.59) | MAPK1MAPKAPK2MAP2K1TLR7NPC1 | |
| Fumaric Acid SCHEMBL6975157 | 0.80 | KDM4E (0.51) | MAPK1MAPKAPK2MAP2K1SMN1; SMN2MAPT | |
| Maleic Acid SCHEMBL6975142 | 0.80 | KDM4E (0.51) | MAPK1MAPKAPK2MAP2K1SMN1; SMN2MAPT | |
| Hydrochloric Acid SCHEMBL6974633 | 0.80 | NPC1 (0.61) | GCKMAPK1MAPKAPK2MAP2K1SIGMAR1 | |
| Fumaric Acid SCHEMBL6963761 | 0.80 | HPGD (0.58) | MAPK1MAPKAPK2MAP2K1MEN1KMT2A | |
| Fumaric Acid SCHEMBL6963773 | 0.80 | HPGD (0.58) | MAPK1MAPKAPK2MAP2K1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL6975603 | 0.79 | KMT2A (0.56) | MAPK1MAPKAPK2MAP2K1NPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0870765-B1 | AMINOTHIAZOLE DERIVATIVES, DRUG CONTAINING THE SAME AND INTERMEDIATE IN THE PRODUCTION OF THE COMPOUNDS | ZERIA PHARM CO LTD (JP) | 2003-11-19 | — | — | EP | disclosed |
| US-5981557-A | HAVING IMPROVING EFFECTS ON THE DYSMOTILITY IN THE GASTROINTESTINAL TRACT | ZERIA PHARMACEUTICAL CO., LTD. (JP) | 1999-11-09 | — | — | US | disclosed |
| EP-0870765-A1 | AMINOTHIAZOLE DERIVATIVES, DRUG CONTAINING THE SAME AND INTERMEDIATE IN THE PRODUCTION OF THE COMPOUNDS | ZERIA PHARMACEUTICAL CO., LTD. (JP) | 1998-10-14 | — | — | EP | disclosed |