SCHEMBL28098623

SCHEMBL28098623

O=C(c1cc(Cl)ccc1O)c1cc(O)c(O)cc1Cl

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 1/20 0.60
CA2 P00918 1/20 0.60
P2RX1 P51575 4/20 0.50
PKM P14618 2/20 0.50
GAA P10253 1/20 0.50
KCNMA1 Q12791 1/20 0.50
TMPRSS4 Q9NRS4 3/20 0.49
P2RX4 Q99571 2/20 0.49
P2RX7 Q99572 2/20 0.49
TSHR P16473 2/20 0.48
HSD17B10 Q99714 2/20 0.48
CASP1 P29466 2/20 0.47
TP53 P04637 2/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
HPGD P15428 2/20 0.47
ALOX15 P16050 2/20 0.47
ALDH1A1 P00352 1/20 0.47
CYP1A2 P05177 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6966672 0.90 CA1 (0.72) CA1CA2P2RX1PKMGAA
SCHEMBL145258 0.81 RECQL (0.70) CA1CA2PKMGAAKCNMA1
SCHEMBL5962842 0.81 GSTA1 (0.62) CA1CA2P2RX1PKMGAA
SCHEMBL6270612 0.80 TSHR (0.52) CA1CA2PKMGAATSHR
SCHEMBL8160214 0.79 ALDH1A1 (0.71) CA1CA2TSHRHSD17B10CASP1
SCHEMBL9779330 0.78 CA1 (0.62) CA1CA2P2RX1KCNMA1TMPRSS4
SCHEMBL14419305 0.77 CA1 (0.60) CA1CA2P2RX1PKMGAA
SCHEMBL9450719 0.77 CA1 (0.70) CA1CA2PKMGAAKCNMA1
SCHEMBL11745694 0.77 CA1 (0.55) CA1CA2P2RX1KCNMA1TMPRSS4
SCHEMBL29389634 0.76 MAPT (0.66) CA1CA2GAAKCNMA1TMPRSS4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105884657-B The chloro benzophenone analog derivative of n-formyl sarcolysine acyloxy substitution 山西医科大学 2017-08-25 CN disclosed
CN-105884657-A Nitrogen Formyloxy-substituted chlorobenzophenone derivative 山西医科大学 2016-08-24 CN disclosed