Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 13/20 | 0.59 |
| ▸ | MMP1 | P03956 | 6/20 | 0.59 |
| ▸ | CTSB | P07858 | 3/20 | 0.51 |
| ▸ | CTSL | P07711 | 2/20 | 0.51 |
| ▸ | CTSS | P25774 | 2/20 | 0.51 |
| ▸ | CTSK | P43235 | 2/20 | 0.51 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | GLS | O94925 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6966746 | 1.00 | MMP3 (0.59) | MMP3MMP1CTSBCTSLCTSS | |
| SCHEMBL6970256 | 0.86 | MMP3 (0.54) | MMP3MMP1MMP2 | |
| SCHEMBL6970251 | 0.86 | MMP3 (0.54) | MMP3MMP1MMP2 | |
| SCHEMBL6964283 | 0.86 | MMP3 (0.65) | MMP3MMP1MMP2 | |
| SCHEMBL6964276 | 0.86 | MMP3 (0.65) | MMP3MMP1MMP2 | |
| SCHEMBL6962504 | 0.84 | MMP3 (0.55) | MMP3MMP1CTSLMMP2GLS | |
| SCHEMBL6962508 | 0.84 | MMP3 (0.55) | MMP3MMP1CTSLMMP2GLS | |
| SCHEMBL6968594 | 0.84 | MMP3 (0.71) | MMP3MMP1CTSLCTSSCTSK | |
| SCHEMBL6963754 | 0.83 | MMP3 (0.72) | MMP3MMP1MMP2 | |
| SCHEMBL6963762 | 0.83 | MMP3 (0.72) | MMP3MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021424-B1 | THIADIAZOLE AMIDE MMP INHIBITORS | UPJOHN CO (US) | 2003-02-26 | — | — | EP | claimed |
| EP-1021424-A1 | THIADIAZOLE AMIDE MMP INHIBITORS | PHARMACIA & UPJOHN COMPANY (US) | 2000-07-26 | — | — | EP | claimed |
| WO-1997048688-A1 | THIADIAZOLE AMIDE MMP INHIBITORS | PHARMACIA & UPJOHN COMPANY (US) | 1997-12-24 | — | — | WO | claimed |
| EP-1021424-B1 | THIADIAZOLE AMIDE MMP INHIBITORS | UPJOHN CO (US) | 2003-02-26 | — | — | EP | disclosed |
| US-5830869-A | METALLOPROTEASE INHIBITOR | PHARMACIA & UPJOHN COMPANY | 1998-11-03 | — | — | US | disclosed |