Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | UBE2T | Q9NPD8 | 1/20 | 0.37 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | HTT | P42858 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6705401 | 0.86 | GAA (0.38) | NPC1RAB9AGAAMAPK1UBE2T | |
| SCHEMBL5796120 | 0.86 | NPC1 (0.53) | NPC1RAB9AGAAMAPK1UBE2T | |
| SCHEMBL2835433 | 0.82 | UBE2T (0.58) | NPC1RAB9AGAAMAPK1UBE2T | |
| SCHEMBL1451349 | 0.82 | HDAC6 (0.44) | GAAUBE2TASIC3MAPTKDM4E | |
| SCHEMBL4240549 | 0.81 | TLR8 (0.37) | NPC1RAB9AGAAMAPK1UBE2T | |
| SCHEMBL2096363 | 0.81 | DRD2 (0.40) | NPC1RAB9AGAAMAPK1MAPT | |
| SCHEMBL693161 | 0.76 | SMN1; SMN2 (0.47) | NPC1RAB9AGAAMAPTKDM4E | |
| SCHEMBL322456 | 0.73 | UBE2T (0.66) | NPC1RAB9AGAAMAPK1UBE2T | |
| SCHEMBL6972136 | 0.73 | CASR (0.36) | — | |
| SCHEMBL15009340 | 0.72 | GAA (0.38) | NPC1RAB9AGAAMAPK1UBE2T |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1329160-A2 | 4-ACYLAMINOPYRAZOLE DERIVATIVES | Sankyo Company, Limited (JP) | 2003-07-23 | — | — | EP | disclosed |