Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 12/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 11/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13069827 | 0.86 | L3MBTL1 (0.45) | SLC6A4SLC6A2SLC6A3KCNH2L3MBTL1 | |
| SCHEMBL6969342 | 0.85 | SLC6A4 (0.47) | SLC6A4SLC6A2SLC6A3KCNH2L3MBTL1 | |
| SCHEMBL9144078 | 0.85 | SLC6A4 (0.50) | SLC6A4SLC6A2SLC6A3KCNH2OPRM1 | |
| SCHEMBL1290745 | 0.84 | SLC6A4 (0.42) | SLC6A4SLC6A2SLC6A3KCNH2L3MBTL1 | |
| SCHEMBL23487077 | 0.84 | SLC6A4 (0.49) | SLC6A4SLC6A2SLC6A3KCNH2OPRM1 | |
| SCHEMBL4610590 | 0.84 | SLC6A2 (0.49) | SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL5255389 | 0.84 | SLC6A4 (0.40) | SLC6A4SLC6A2SLC6A3KCNH2L3MBTL1 | |
| SCHEMBL297266 | 0.82 | SLC6A4 (0.49) | SLC6A4SLC6A2SLC6A3KCNH2L3MBTL1 | |
| SCHEMBL1309394 | 0.82 | SLC6A4 (0.43) | SLC6A4SLC6A2SLC6A3KCNH2 | |
| SCHEMBL6392802 | 0.82 | L3MBTL1 (0.54) | L3MBTL1MEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023224963-A1 | DUAL-ACTING ANGIOTENSIN AND ENDOTHELIN RECEPTOR ANTAGONISTS | ARIA PHARMACEUTICALS, INC. (US) | 2023-11-23 | — | — | WO | disclosed |
| EP-0897913-B1 | 4-carboxamido piperidine derivatives and their use as neurokinine antagonists | ASTRAZENECA AB (SE) | 2003-04-16 | — | — | EP | disclosed |
| EP-0667858-B1 | 4-CARBOXOAMIDO PIPERIDINE DERIVATIVES, INTERMEDIATES AND USE AS NEUROKININ ANTAGONISTS | ZENECA LTD (GB) | 1999-08-25 | — | — | EP | disclosed |
| EP-0897913-A1 | 4-carboxamido piperidine derivatives and their use as neurokinine antagonists | ZENECA LIMITED (GB) | 1999-02-24 | — | — | EP | disclosed |
| US-5576333-A | ASTHMA TREATMENT | ZENECA LIMITED (GB) | 1996-11-19 | — | — | US | disclosed |
| US-5559131-A | ANTAGONISTS OF TACHYKININS AT THE NEUROKININ 2 RECEPTOR, ANTIASTHMA | ZENECA LIMITED (GB) | 1996-09-24 | — | — | US | disclosed |
| US-5559132-A | ANTAGONIST OF TACHYKININS AT THE NEUROKININ 2 RECEPTOR, ANTIASTHMA | ZENECA LIMITED (GB) | 1996-09-24 | — | — | US | disclosed |
| EP-0667858-A1 | 4-CARBOXOAMIDO PIPERIDINE DERIVATIVES, INTERMEDIATES AND USE AS NEUROKININ ANTAGONISTS | ZENECA LIMITED (GB) | 1995-08-23 | — | — | EP | disclosed |
| US-5391556-A | Thrombin inhibitors | KARL THOMAE GMBH (DE) | 1995-02-21 | — | — | US | disclosed |
| CN-1094723-A | Carboxamide derivative | ZENECA LTD (GB) | 1994-11-09 | — | — | CN | disclosed |
| WO-1994010146-A1 | 4-CARBOXOAMIDO PIPERIDINE DERIVATIVES, INTERMEDIATES AND USE AS NEUROKININ ANTAGONISTS | ZENECA LIMITED (GB) | 1994-05-11 | — | — | WO | disclosed |