SCHEMBL6969342

SCHEMBL6969342

CCCC(=O)N(CC)C1CCNCC1

nearest known ligand 0.47

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 12/20 0.47
SLC6A2 P23975 11/20 0.47
SLC6A3 Q01959 7/20 0.47
L3MBTL1 Q9Y468 1/20 0.44
KCNH2 Q12809 3/20 0.41
TACR1 P25103 3/20 0.40
OPRM1 P35372 1/20 0.37
GNAI3 P08754 1/20 0.37
GNAO1 P09471 1/20 0.37
GNAI1 P63096 1/20 0.37
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6967580 0.85 SLC6A4 (0.52) SLC6A4SLC6A2SLC6A3L3MBTL1KCNH2
SCHEMBL19002588 0.83 L3MBTL1 (0.59) L3MBTL1OPRM1MEN1KMT2A
SCHEMBL19021784 0.81 L3MBTL1 (0.62) L3MBTL1MEN1KMT2A
SCHEMBL1290745 0.81 SLC6A4 (0.42) SLC6A4SLC6A2SLC6A3L3MBTL1KCNH2
SCHEMBL5255389 0.81 SLC6A4 (0.40) SLC6A4SLC6A2SLC6A3L3MBTL1KCNH2
SCHEMBL7276552 0.80 SLC6A4 (0.42) SLC6A4SLC6A2SLC6A3KCNH2GNAI3
SCHEMBL297266 0.79 SLC6A4 (0.49) SLC6A4SLC6A2SLC6A3L3MBTL1KCNH2
Hydrochloric Acid SCHEMBL3740415 0.78 SLC6A4 (0.48) SLC6A4SLC6A2SLC6A3KCNH2GNAI3
SCHEMBL27348780 0.78 SLC6A4 (0.40) SLC6A4SLC6A2SLC6A3L3MBTL1KCNH2
SCHEMBL27787052 0.78 OPRM1 (0.65) SLC6A4SLC6A2SLC6A3L3MBTL1KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0897913-B1 4-carboxamido piperidine derivatives and their use as neurokinine antagonists ASTRAZENECA AB (SE) 2003-04-16 EP disclosed
EP-0667858-B1 4-CARBOXOAMIDO PIPERIDINE DERIVATIVES, INTERMEDIATES AND USE AS NEUROKININ ANTAGONISTS ZENECA LTD (GB) 1999-08-25 EP disclosed
EP-0897913-A1 4-carboxamido piperidine derivatives and their use as neurokinine antagonists ZENECA LIMITED (GB) 1999-02-24 EP disclosed
US-5576333-A ASTHMA TREATMENT ZENECA LIMITED (GB) 1996-11-19 US disclosed
US-5559131-A ANTAGONISTS OF TACHYKININS AT THE NEUROKININ 2 RECEPTOR, ANTIASTHMA ZENECA LIMITED (GB) 1996-09-24 US disclosed
US-5559132-A ANTAGONIST OF TACHYKININS AT THE NEUROKININ 2 RECEPTOR, ANTIASTHMA ZENECA LIMITED (GB) 1996-09-24 US disclosed
EP-0667858-A1 4-CARBOXOAMIDO PIPERIDINE DERIVATIVES, INTERMEDIATES AND USE AS NEUROKININ ANTAGONISTS ZENECA LIMITED (GB) 1995-08-23 EP disclosed
WO-1994010146-A1 4-CARBOXOAMIDO PIPERIDINE DERIVATIVES, INTERMEDIATES AND USE AS NEUROKININ ANTAGONISTS ZENECA LIMITED (GB) 1994-05-11 WO disclosed