Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 3/20 | 0.36 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 4/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.34 |
| ▸ | IP6K1 | Q92551 | 2/20 | 0.34 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PRCP | P42785 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6965169 | 0.87 | MGLL (0.45) | MGLLPTGER1PTGDR2 | |
| SCHEMBL6976701 | 0.86 | PTGER1 (0.42) | MGLLPTGER1PTGDR2IP6K1C5AR1 | |
| SCHEMBL6969877 | 0.83 | MCHR1 (0.39) | MGLLPTGER1PTGDR2IP6K1ALDH1A1 | |
| SCHEMBL6973204 | 0.83 | MEN1 (0.39) | MGLLPTGER1PTGDR2ALDH1A1GAA | |
| Hydrochloric Acid SCHEMBL6977813 | 0.83 | MEN1 (0.38) | MGLLPTGER1PTGDR2ALDH1A1GAA | |
| SCHEMBL6968399 | 0.82 | KMT2A (0.40) | MGLLPTGER1PTGDR2ALDH1A1GAA | |
| SCHEMBL6977878 | 0.79 | KDM4E (0.40) | PTGER1C5AR1ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL6969218 | 0.79 | KDM4E (0.39) | PTGER1C5AR1ALDH1A1MAPT | |
| SCHEMBL6974047 | 0.78 | PTGER1 (0.37) | MGLLPTGER1IP6K1C5AR1ALDH1A1 | |
| SCHEMBL6967538 | 0.77 | HTR1A (0.37) | MGLLPTGER1C5AR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6566376-B1 | For therapy of chemokine receptor related diseases and conditions such as rheumatoid arthritis, chronic obstructive pulmonary disease | ASTRAZENECA UK LIMITED (GB) | 2003-05-20 | — | — | US | claimed |
| EP-1202984-B1 | DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LTD (GB) | 2003-03-05 | — | — | EP | claimed |
| US-6566376-B1 | For therapy of chemokine receptor related diseases and conditions such as rheumatoid arthritis, chronic obstructive pulmonary disease | ASTRAZENECA UK LIMITED (GB) | 2003-05-20 | — | — | US | disclosed |
| EP-1202984-B1 | DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LTD (GB) | 2003-03-05 | — | — | EP | disclosed |