Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 5/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6843595 | 0.77 | HTR1A (0.50) | HTR1AHPGDMAPTLMNAPOLB | |
| SCHEMBL6965306 | 0.75 | HTR1A (0.43) | HTR1AMAPTGAARAD52 | |
| SCHEMBL8120002 | 0.74 | HTR7 (0.61) | HTR1ALMNAHTR7 | |
| SCHEMBL4084811 | 0.72 | DAO (0.55) | LMNASMN1; SMN2DAO | |
| SCHEMBL8486092 | 0.72 | HTR1A (0.44) | HTR1AMAPTLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL12124686 | 0.71 | SLC6A2 (0.67) | HPGDMAPTLMNAPOLBMAPK1 | |
| SCHEMBL6843885 | 0.70 | HTR1A (0.52) | HTR1AHPGDMAPTLMNAPOLB | |
| SCHEMBL9757317 | 0.70 | RAD52 (0.54) | HTR1AMAPTLMNAPOLBMAPK1 | |
| SCHEMBL9757259 | 0.70 | HTR1A (0.52) | HTR1AMAPTLMNAMAPK1GAA | |
| SCHEMBL6961264 | 0.70 | HTR1A (0.52) | HTR1AMAPTLMNAMAPK1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0775118-A1 | BENZIMIDAZOLE DERIVATIVES HAVING DOPAMINERGIC ACTIVITY | PFIZER INC. (US) | 1997-05-28 | — | — | EP | claimed |
| WO-1996004250-A1 | BENZIMIDAZOLE DERIVATIVES HAVING DOPAMINERGIC ACTIVITY | PFIZER INC. (US) | 1996-02-15 | — | — | WO | claimed |
| EP-0775118-B1 | BENZIMIDAZOLE DERIVATIVES HAVING DOPAMINERGIC ACTIVITY | PFIZER (US) | 2003-06-04 | — | — | EP | disclosed |
| WO-1996004250-A1 | BENZIMIDAZOLE DERIVATIVES HAVING DOPAMINERGIC ACTIVITY | PFIZER INC. (US) | 1996-02-15 | — | — | WO | disclosed |