Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 11/20 | 0.61 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.50 |
| ▸ | DRD3 | P35462 | 2/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MLNR | O43193 | 1/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8135911 | 0.76 | HTR7 (1.00) | HTR7P2RX7ADORA3CHRM1SLC6A4 | |
| SCHEMBL737677 | 0.75 | MEN1 (0.63) | HTR7P2RX7ADORA3CHRM1SLC6A4 | |
| SCHEMBL8135691 | 0.74 | HTR7 (1.00) | HTR7P2RX7ADORA3CHRM1SLC6A4 | |
| SCHEMBL6967924 | 0.74 | HTR1A (0.49) | HTR7LMNAHTR1A | |
| SCHEMBL10284697 | 0.70 | LMNA (0.64) | HTR7P2RX7ADORA3CHRM1SLC6A4 | |
| SCHEMBL28851967 | 0.69 | CHRNA7 (0.49) | CHRM1OPRM1LMNACHRM2CYP3A4 | |
| SCHEMBL11199974 | 0.68 | P2RX7 (1.00) | HTR7P2RX7ADORA3CHRM1SLC6A4 | |
| SCHEMBL8248960 | 0.68 | LMNA (0.64) | HTR7P2RX7MEN1LMNACYP1A2 | |
| SCHEMBL29695523 | 0.68 | CYP1A2 (0.74) | HTR7P2RX7ADORA3MEN1LMNA | |
| SCHEMBL763168 | 0.68 | CYP1A2 (0.74) | HTR7P2RX7ADORA3MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526434-B1 | Benzimidazolone derivatives as 5-HT1A and 5-HT2 antagonists | BOEHRINGER INGELHEIM ITALIA (IT) | 2000-04-19 | — | — | EP | disclosed |
| US-5576318-A | FOR TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | BOEHRINGER INGELHEIM ITALIA S.P.A. (IT) | 1996-11-19 | — | — | US | disclosed |
| WO-1993003016-A1 | BENZIMIDAZOLONE DERIVATIVES AS 5-HT1A AND 5-HT2 ANTAGONISTS | BOEHRINGER INGELHEIM ITALIA S.P.A. (IT) | 1993-02-18 | — | — | WO | disclosed |
| EP-0526434-A1 | Benzimidazolone derivatives as 5-HT1A and 5-HT2 antagonists | BOEHRINGER INGELHEIM ITALIA S.p.A. (IT) | 1993-02-03 | — | — | EP | disclosed |