Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 4/20 | 0.48 |
| ▸ | CDK8 | P49336 | 4/20 | 0.48 |
| ▸ | CDK19 | Q9BWU1 | 4/20 | 0.48 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 3/20 | 0.34 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.34 |
| ▸ | C1S | P09871 | 2/20 | 0.34 |
| ▸ | IKBKB | O14920 | 2/20 | 0.33 |
| ▸ | PLK4 | O00444 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6977569 | 0.84 | CCNC (0.53) | CCNCCDK8CDK19CDK9IKBKB | |
| SCHEMBL6975301 | 0.72 | CCNC (0.51) | CCNCCDK8CDK19CDK9IKBKB | |
| SCHEMBL6967359 | 0.69 | CCNC (0.56) | CCNCCDK8CDK19CDK9IKBKB | |
| SCHEMBL7700630 | 0.69 | CCNC (0.47) | CCNCCDK8CDK19CDK9 | |
| SCHEMBL6980131 | 0.66 | CCNC (0.55) | CCNCCDK8CDK19CDK9IKBKB | |
| SCHEMBL6978882 | 0.64 | CCNC (0.55) | CCNCCDK8CDK19CDK9 | |
| SCHEMBL7248663 | 0.64 | CCNC (0.86) | CCNCCDK8CDK19CDK9MEN1 | |
| SCHEMBL28585958 | 0.61 | USP7 (0.39) | BCAT2IKBKBCHEK2PIM1MEN1 | |
| SCHEMBL6890917 | 0.61 | IKBKB (0.40) | IKBKBMAPK1MEN1KMT2AHSD17B10 | |
| SCHEMBL739660 | 0.61 | TDO2 (0.61) | TDO2AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1120415-B1 | SUBSTITUTED ISOXAZOLYLTHIOPHENE COMPOUNDS | TAISHO PHARMACEUTICAL CO LTD (JP) | 2003-07-23 | — | — | EP | disclosed |
| US-6355663-B1 | AN ENHANCING AGENT FOR THE ACTION OF CELL DIFFERENTIATION INDUCTION FACTORS FOR BONE DISORDERS AND NERVOUS SYSTEM DISORDERS | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2002-03-12 | — | — | US | disclosed |
| EP-1120415-A1 | SUBSTITUTED ISOXAZOLYLTHIOPHENE COMPOUNDS | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2001-08-01 | — | — | EP | disclosed |