Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 9/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.37 |
| ▸ | TUBB | P07437 | 1/20 | 0.37 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.37 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.37 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.37 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.37 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.37 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.37 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.37 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.37 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.37 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.37 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.37 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.37 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1218666 | 0.84 | MEN1 (0.53) | TDO2MAPTL3MBTL1TUBB4ATUBB | |
| SCHEMBL23596809 | 0.83 | TDO2 (0.49) | TDO2MAPTL3MBTL1GPR55TUBB4A | |
| SCHEMBL5782694 | 0.82 | TDO2 (0.47) | TDO2MAPTL3MBTL1TUBB4ATUBB | |
| SCHEMBL31213506 | 0.82 | CA2 (0.56) | TDO2LMNA | |
| SCHEMBL23596603 | 0.81 | TDO2 (0.46) | TDO2MAPTL3MBTL1GPR55TUBB4A | |
| SCHEMBL4448263 | 0.81 | HPGD (0.50) | TDO2MAPTL3MBTL1LMNA | |
| SCHEMBL23596950 | 0.80 | TDO2 (0.46) | TDO2MAPTL3MBTL1GPR55 | |
| SCHEMBL23596152 | 0.78 | TDO2 (0.44) | TDO2MAPTL3MBTL1GPR55 | |
| SCHEMBL23596535 | 0.78 | TDO2 (0.47) | TDO2MAPTL3MBTL1TUBB4ATUBB | |
| SCHEMBL23596934 | 0.77 | TDO2 (0.46) | TDO2MAPTL3MBTL1GPR55TUBB4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106349180-B | 4, 5-diphenyl isoxazole derivative and preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2020-05-19 | — | — | CN | claimed |
| CN-106349180-A | 4,5-diphenyl isoxazole derivative as well as preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2017-01-25 | — | — | CN | claimed |
| EP-2429987-A2 | AMIDE COMPOUND, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | Korea Research Institute Of Chemical Technology (KR) | 2012-03-21 | — | — | EP | claimed |
| WO-2010131922-A2 | AMIDE COMPOUND, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2010-11-18 | — | — | WO | claimed |
| CN-106349180-B | 4, 5-diphenyl isoxazole derivative and preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2020-05-19 | — | — | CN | disclosed |
| CN-106349180-B | 4, 5-diphenyl isoxazole derivative and preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2020-05-19 | — | — | CN | disclosed |
| CN-106349180-B | 4, 5-diphenyl isoxazole derivative and preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2020-05-19 | — | — | CN | disclosed |
| CN-107095867-B | Application of HSP90 inhibitor in preparation of medicine for preventing and treating aortic disease | 上海长海医院 | 2020-01-17 | — | — | CN | disclosed |
| CN-107095867-A | A kind of HSP90 inhibitor is preparing the purposes in preventing and treating arotic disease medicine | 上海长海医院 | 2017-08-29 | — | — | CN | disclosed |
| CN-106349180-A | 4,5-diphenyl isoxazole derivative as well as preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2017-01-25 | — | — | CN | disclosed |
| CN-106349180-A | 4,5-diphenyl isoxazole derivative as well as preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2017-01-25 | — | — | CN | disclosed |
| CN-106349180-A | 4,5-diphenyl isoxazole derivative as well as preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2017-01-25 | — | — | CN | disclosed |
| WO-1999064415-A1 | SULFONYLBENZENE COMPOUNDS AS ANTI-INFLAMMATORY/ANALGESIC AGENTS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-12-16 | — | — | WO | disclosed |
| US-5985902-A | TREATING INFLAMMATION AND INFLAMMATION-ASSOCIATED DISORDERS, SUCH AS ARTHRITIS | G.D. SEARLE & CO. (US) | 1999-11-16 | — | — | US | disclosed |
| EP-0938482-A1 | 5-SUBSTITUTED AND 5,5-DISUBSTITUTED-3,4-DIHYDROXY-2(5H)-FURANONES AND METHODS OF USE THEREFOR | Oxis International, Inc. (US) | 1999-09-01 | — | — | EP | disclosed |
| US-5859257-A | ANTIINFLAMMATORY, ANTIARTHRITIC AGENTS | G. D. SEARLE & CO. (US) | 1999-01-12 | — | — | US | disclosed |
| WO-1998007714-A1 | 5-SUBSTITUTED AND 5,5-DISUBSTITUTED-3,4-DIHYDROXY-2(5H)-FURANONES AND METHODS OF USE THEREFOR | OXIS INTERNATIONAL, INC. (US) | 1998-02-26 | — | — | WO | disclosed |
| EP-0809636-A1 | SUBSTITUTED ISOXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-12-03 | — | — | EP | disclosed |
| US-5633272-A | Substituted isoxazoles for the treatment of inflammation | PHARMACIA & UPJOHN COMPANY LLC | 1997-05-27 | — | — | US | disclosed |
| WO-1996025405-A1 | SUBSTITUTED ISOXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-22 | — | — | WO | disclosed |