Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 8/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | HTR1B | P28222 | 1/20 | 0.45 |
| ▸ | HTR1F | P30939 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.37 |
| ▸ | PRPS1 | P60891 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 2/20 | 0.36 |
| ▸ | KRAS | P01116 | 1/20 | 0.36 |
| ▸ | KHK | P50053 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6976187 | 0.81 | HTR6 (0.39) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL6968868 | 0.79 | HTR6 (0.50) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL6972524 | 0.75 | HTR6 (0.77) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL6968879 | 0.74 | DYRK1A (0.42) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL6965704 | 0.73 | HTR6 (0.49) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL6967984 | 0.73 | HTR6 (0.49) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL6965707 | 0.73 | HTR6 (0.49) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL6968124 | 0.72 | HTR6 (0.36) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL7006184 | 0.72 | SLC6A4 (0.36) | HTR6PRPS1SLC6A4 | |
| SCHEMBL8483890 | 0.71 | HTR6 (0.61) | HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944595-B1 | 5-CYCLO INDOLE COMPOUNDS AS 5-HT1D RECEPTOR LIGANDS | NPS ALLELIX CORP (CA) | 2003-10-01 | — | — | EP | disclosed |
| US-5998438-A | SEROTONIN RECEPTOR ANTAGONIST; HEADACHE THERAPY | ALLELIX BIOPHARMACEUTICALS, INC. (CA) | 1999-12-07 | — | — | US | disclosed |
| EP-0944595-A1 | 5-CYCLO INDOLE COMPOUNDS AS 5-HT1D RECEPTOR LIGANDS | Allelix Biopharmaceuticals Inc. (CA) | 1999-09-29 | — | — | EP | disclosed |
| WO-1998023587-A1 | 5-CYCLO INDOLE COMPOUNDS AS 5-HT1D RECEPTOR LIGANDS | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 1998-06-04 | — | — | WO | disclosed |