Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 2/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | HTR1F | P30939 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8209787 | 0.88 | SLC6A2 (0.40) | HTR6SLC6A2SLC6A4SLC6A3KMT2A | |
| SCHEMBL8208589 | 0.88 | KMT2A (0.44) | HTR6SLC6A2SLC6A4SLC6A3KDM4E | |
| SCHEMBL1697462 | 0.87 | PRPS1 (0.35) | MBTD1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8213329 | 0.83 | PTGS1 (0.38) | HTR6SLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL8200926 | 0.80 | KMT2A (0.47) | HTR6KDM4EALDH1A1THRBKMT2A | |
| SCHEMBL8208574 | 0.79 | AKR1C3 (0.42) | SLC6A2SLC6A4SLC6A3KMT2A | |
| SCHEMBL8208559 | 0.78 | KMT2A (0.51) | HTR6KDM4EALDH1A1THRBKMT2A | |
| SCHEMBL7470825 | 0.78 | HTR1A (0.38) | HTR6SLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL8201598 | 0.77 | AKR1C3 (0.46) | KMT2A | |
| SCHEMBL8209083 | 0.75 | PDE4B (0.38) | HTR6SLC6A2SLC6A4SLC6A3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6100291-A | FOR TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 2000-08-08 | — | — | US | claimed |
| WO-1999047516-A1 | 3-(2-PYRROLIDINYLMETHYL)-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | SLASSI ABDELMALIK (CA) | 1999-09-23 | — | — | WO | claimed |
| EP-0944595-B1 | 5-CYCLO INDOLE COMPOUNDS AS 5-HT1D RECEPTOR LIGANDS | NPS ALLELIX CORP (CA) | 2003-10-01 | — | — | EP | disclosed |
| US-6100291-A | FOR TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 2000-08-08 | — | — | US | disclosed |
| US-5998438-A | SEROTONIN RECEPTOR ANTAGONIST; HEADACHE THERAPY | ALLELIX BIOPHARMACEUTICALS, INC. (CA) | 1999-12-07 | — | — | US | disclosed |
| EP-0944595-A1 | 5-CYCLO INDOLE COMPOUNDS AS 5-HT1D RECEPTOR LIGANDS | Allelix Biopharmaceuticals Inc. (CA) | 1999-09-29 | — | — | EP | disclosed |
| WO-1999047516-A1 | 3-(2-PYRROLIDINYLMETHYL)-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | SLASSI ABDELMALIK (CA) | 1999-09-23 | — | — | WO | disclosed |
| WO-1998023587-A1 | 5-CYCLO INDOLE COMPOUNDS AS 5-HT1D RECEPTOR LIGANDS | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 1998-06-04 | — | — | WO | disclosed |