Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UCHL1 | P09936 | 1/20 | 0.56 |
| ▸ | MTTP | P55157 | 13/20 | 0.52 |
| ▸ | APOB | P04114 | 12/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.45 |
| ▸ | SMO | Q99835 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7628750 | 0.90 | MTTP (0.55) | MTTPAPOBSMOGAAKDM4E | |
| SCHEMBL6974148 | 0.90 | MTTP (0.59) | MTTPAPOBJAK2JAK3PTK2 | |
| SCHEMBL13717401 | 0.81 | UCHL1 (0.57) | UCHL1 | |
| SCHEMBL13717406 | 0.81 | UCHL1 (0.57) | UCHL1 | |
| SCHEMBL8587342 | 0.81 | APOB (0.52) | MTTPAPOBJAK2JAK3PTK2 | |
| SCHEMBL6966884 | 0.80 | APOB (0.61) | MTTPAPOBSMOGAASMN1; SMN2 | |
| SCHEMBL14585869 | 0.78 | MTTP (0.57) | MTTPAPOBSMOGAASMN1; SMN2 | |
| SCHEMBL6965797 | 0.78 | MTTP (0.58) | MTTPAPOBSMOGAASMN1; SMN2 | |
| SCHEMBL6809447 | 0.78 | MTTP (0.57) | MTTPAPOBSMOGAASMN1; SMN2 | |
| SCHEMBL6973765 | 0.77 | APOB (0.58) | MTTPAPOBSMOGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832069-B1 | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION | PFIZER (US) | 2003-03-05 | — | — | EP | disclosed |
| EP-1181954-A2 | Biphenyl-2-carboxylic acid-tetrahydro-isoquinolin-6-yl amide derivatives, their preparation and use as inhibitors of microsomal triglyceride transfer protein and/or apolipoprotein B (ApoB) secretion | PFIZER INC. (US) | 2002-02-27 | — | — | EP | disclosed |
| US-5919795-A | ATHEROSCLEROSIS THERAPY | PFIZER INC. (US) | 1999-07-06 | — | — | US | disclosed |