Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOB | P04114 | 11/20 | 0.52 |
| ▸ | MTTP | P55157 | 10/20 | 0.52 |
| ▸ | JAK2 | O60674 | 2/20 | 0.51 |
| ▸ | JAK3 | P52333 | 2/20 | 0.51 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.48 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | RAF1 | P04049 | 1/20 | 0.45 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6974148 | 0.91 | MTTP (0.59) | APOBMTTPJAK2JAK3PTK2 | |
| SCHEMBL9232371 | 0.86 | NAMPT (0.52) | APOBMTTPTMPRSS2NAMPT | |
| SCHEMBL8470621 | 0.81 | APOB (0.47) | APOBMTTPTMPRSS2 | |
| SCHEMBL8200962 | 0.81 | MTTP (0.52) | APOBMTTPJAK2JAK3PTK2 | |
| SCHEMBL8591888 | 0.81 | SMO (0.46) | APOBMTTPTMPRSS2NAMPT | |
| SCHEMBL6969150 | 0.81 | UCHL1 (0.56) | APOBMTTPJAK2JAK3PTK2 | |
| SCHEMBL1187947 | 0.81 | ESR2 (0.58) | JAK2JAK3PTK2ESR2NAMPT | |
| SCHEMBL8207493 | 0.81 | ITGB3 (0.55) | APOBMTTPTMPRSS2 | |
| SCHEMBL14585872 | 0.80 | MTTP (0.54) | APOBMTTPJAK2JAK3PTK2 | |
| SCHEMBL7806887 | 0.80 | NAMPT (0.56) | APOBMTTPJAK2JAK3PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944602-A1 | APO B-SECRETION/MTP INHIBITORY AMIDES | PFIZER INC. (US) | 1999-09-29 | — | — | EP | disclosed |
| WO-1998023593-A1 | APO B-SECRETION/MTP INHIBITORY AMIDES | PFIZER INC. (US) | 1998-06-04 | — | — | WO | disclosed |