Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 3/20 | 0.40 |
| ▸ | MMP9 | P14780 | 3/20 | 0.40 |
| ▸ | MMP13 | P45452 | 3/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6435679 | 0.92 | CYP3A4 (0.46) | DRD2CYP2D6CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6973071 | 0.87 | DRD2 (0.38) | DRD2CYP2D6CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7204028 | 0.80 | MAPT (0.38) | KMT2AMMP1MMP9 | |
| SCHEMBL6966720 | 0.80 | MAPT (0.36) | KMT2AMMP1MMP9 | |
| SCHEMBL6966714 | 0.80 | MAPT (0.36) | KMT2AMMP1MMP9 | |
| SCHEMBL6966717 | 0.80 | MAPT (0.36) | KMT2AMMP1MMP9 | |
| SCHEMBL6968646 | 0.77 | MMP2 (0.51) | DRD2CYP2D6CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7202506 | 0.76 | MAPT (0.35) | KMT2AMMP1MMP9 | |
| SCHEMBL6971622 | 0.76 | MAPT (0.35) | KMT2AMMP1MMP9 | |
| SCHEMBL6963988 | 0.76 | MAPT (0.35) | KMT2AMMP1MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1181017-B1 | METALLOPROTEASE INHIBITORS | PFIZER LTD (GB) | 2003-04-16 | — | — | EP | claimed |