SCHEMBL6969308

SCHEMBL6969308

O=C1CCc2cc(-c3cccc(C(F)(F)F)c3)ccc21

nearest known ligand 0.67

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
PARP10 Q53GL7 1/20 0.67
PARP11 Q9NR21 1/20 0.67
HRH3 Q9Y5N1 2/20 0.55
CYP11B1 P15538 2/20 0.55
CYP11B2 P19099 2/20 0.55
CYP1A2 P05177 1/20 0.55
HSD17B1 P14061 4/20 0.54
ASIC3 Q9UHC3 1/20 0.52
TDP2 O95551 1/20 0.47
DHODH Q02127 1/20 0.46
PGR P06401 1/20 0.46
KIF11 P52732 2/20 0.44
KDM1A O60341 1/20 0.44
MAPK14 Q16539 1/20 0.44
CASP1 P29466 1/20 0.44
CASP7 P55210 1/20 0.44
HSD17B10 Q99714 1/20 0.44
MPL P40238 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4418024 0.91 PARP10 (0.64) PARP10PARP11HRH3CYP11B1CYP11B2
SCHEMBL2706902 0.88 HSD17B1 (0.57) PARP10PARP11HRH3CYP11B1CYP11B2
SCHEMBL2388879 0.84 CASP1 (0.55) PARP10PARP11CYP11B1CYP11B2CYP1A2
SCHEMBL8159275 0.80 PARP10 (1.00) PARP10PARP11HRH3ASIC3TDP2
SCHEMBL4596879 0.80 HSD17B1 (0.65) PARP10PARP11HRH3CYP11B1CYP11B2
SCHEMBL28655414 0.80 HSD17B1 (0.78) PARP10PARP11HRH3CYP11B1CYP11B2
SCHEMBL1745161 0.79 HSD17B1 (0.71) PARP10PARP11HRH3CYP11B1CYP11B2
SCHEMBL6968452 0.78 HRH3 (0.57) PARP10PARP11HRH3CYP11B1CYP11B2
SCHEMBL16193523 0.78 HTR1A (0.48) PARP10PARP11HRH3CYP11B1CYP11B2
SCHEMBL16201911 0.77 HTR1A (0.50) PARP10PARP11ASIC3PGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1119557-B1 INDENO-, NAPHTO- AND BENZOCYCLOHEPTA DIHYDROTHIAZOLE DERIVATIVES, THE PRODUCTION THEREOF AND THEIR USE AS ANORECTIC MEDICAMENTS AVENTIS PHARMA GMBH (DE) 2003-12-03 EP disclosed
US-6291486-B1 PREVENTING OBESITY; ANORECTICS. AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2001-09-18 US disclosed
EP-1119557-A1 INDENO-, NAPHTO- AND BENZOCYCLOHEPTA DIHYDROTHIAZOLE DERIVATIVES, THE PRODUCTION THEREOF AND THEIR USE AS ANORECTIC MEDICAMENTS Aventis Pharma Deutschland GmbH (DE) 2001-08-01 EP disclosed
US-6090833-A EATING DISORDERS; ANTIDIABETIC AGENT AVENTIS PHARMA DEUTSCHAND GMBH (DE) 2000-07-18 US disclosed
WO-2000018749-A1 INDENO-, NAPHTO- AND BENZOCYCLOHEPTA DIHYDROTHIAZOLE DERIVATIVES, THE PRODUCTION THEREOF AND THEIR USE AS ANORECTIC MEDICAMENTS AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2000-04-06 WO disclosed