Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 2/20 | 0.32 |
| ▸ | ACE | P12821 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6972676 | 0.78 | ACE (0.36) | ALDH1A1CYP2D6ACE | |
| SCHEMBL6973366 | 0.76 | ACE (0.41) | KDM4ETP53ACE | |
| SCHEMBL6973729 | 0.76 | ALDH1A1 (0.40) | LMNAKDM4EALDH1A1ACE | |
| SCHEMBL6957854 | 0.76 | GHSR (0.38) | KDM4ECYP2D6ACE | |
| SCHEMBL6960911 | 0.76 | ACE (0.36) | ACE | |
| SCHEMBL6969731 | 0.75 | KCNH2 (0.39) | LMNAKDM4EALDH1A1TP53KCNH2 | |
| SCHEMBL4503987 | 0.75 | F11 (0.40) | KDM4EALDH1A1NPSR1HSD17B10HPGD | |
| SCHEMBL6973580 | 0.75 | ACE (0.35) | CYP2D6ACE | |
| SCHEMBL6973916 | 0.75 | TP53 (0.41) | TP53ACE | |
| SCHEMBL6961352 | 0.75 | ACE (0.40) | LMNAKDM4EALDH1A1TP53NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832069-B1 | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION | PFIZER (US) | 2003-03-05 | — | — | EP | disclosed |