Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
| ▸ | HPGD | P15428 | 2/20 | 0.66 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.57 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.54 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.52 |
| ▸ | GFER | P55789 | 2/20 | 0.52 |
| ▸ | CCR2 | P41597 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | GALR3 | O60755 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | PRKCI | P41743 | 1/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3061254 | 0.82 | L3MBTL1 (0.70) | HSD17B10KDM4EALDH1A1HPGDMCL1 | |
| SCHEMBL30547707 | 0.81 | KDM4E (0.68) | HSD17B10KDM4EALDH1A1HPGDMCL1 | |
| SCHEMBL5599830 | 0.81 | KDM4E (0.68) | HSD17B10KDM4EALDH1A1HPGDMCL1 | |
| SCHEMBL2001537 | 0.81 | HSD17B10 (0.68) | HSD17B10KDM4EALDH1A1HPGDMCL1 | |
| SCHEMBL5889548 | 0.81 | KDM4E (0.68) | HSD17B10KDM4EALDH1A1HPGDMCL1 | |
| SCHEMBL10022665 | 0.80 | MCL1 (0.63) | HSD17B10KDM4EALDH1A1HPGDMCL1 | |
| SCHEMBL986506 | 0.79 | KDM4E (1.00) | HSD17B10KDM4EALDH1A1HPGDMCL1 | |
| SCHEMBL43328 | 0.79 | KDM4E (0.66) | HSD17B10KDM4EALDH1A1HPGDMCL1 | |
| SCHEMBL418126 | 0.79 | MCL1 (1.00) | HSD17B10KDM4EALDH1A1HPGDMCL1 | |
| SCHEMBL12825045 | 0.79 | BRPF1 (0.50) | HSD17B10KDM4EALDH1A1HPGDMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102781914-B | Indole derivatives | TAKEDA PHARMACEUTICAL | 2014-09-17 | — | — | CN | disclosed |
| CN-102781914-A | Indole derivatives | TAKEDA PHARMACEUTICAL | 2012-11-14 | — | — | CN | disclosed |
| US-20120232052-A1 | ARYL CARBOXAMIDE DERIVATIVES AS TTX-S BLOCKERS | RAQUALIA PHARMA INC. (JP) | 2012-09-13 | — | — | US | disclosed |
| CN-102424680-A | Viral polymerase inhibitors | BOEHRINGER INGELHEIM CA LTD | 2012-04-25 | — | — | CN | disclosed |
| CN-1558759-B | Viral polymerase inhibitors | BOEHRINGER INGELHEIM CA LTD | 2012-01-25 | — | — | CN | disclosed |
| CN-1880304-B | Triamide-substituted indoles, benzofuranes and benzothiophenes | PFIZER | 2010-11-24 | — | — | CN | disclosed |
| CN-1522246-B | Triamide-substituted indoles, benzofurans and benzothiophenes | PFIZER | 2010-04-21 | — | — | CN | disclosed |
| CN-1880304-A | Triamide-substituted indoles, benzofuranes and benzothiophenes | PFIZER (US) | 2006-12-20 | — | — | CN | disclosed |
| CN-1558759-A | Viral polymerase inhibitors | ���ָ����Ӣ��ķ���ô�����˾ | 2004-12-29 | — | — | CN | disclosed |
| CN-1522246-A | Triamide-substituted indoles, benzofurans and benzothiophenes as inhibitors of microsomal triglyceride transfer protein (MTP) and/or apolipoprotein B (APO B) secretion | �Ʒ� | 2004-08-18 | — | — | CN | disclosed |
| EP-0937070-B1 | BENZOHETEROCYCLIC DISTAMYCIN DERIVATIVES, PROCESS FOR PREPARING THEM, AND THEIR USE AS ANTITUMOR AND ANTIVIRAL AGENTS | PHARMACIA ITALIA SPA (IT) | 2003-12-03 | — | — | EP | disclosed |
| CN-1067988-C | Indoloylguanidine derivatives | SUMITOMO PHARMACEUTICS K K (JP) | 2001-07-04 | — | — | CN | disclosed |
| US-6153642-A | Benzoheterocyclic distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-11-28 | — | — | US | disclosed |
| CN-1051301-C | Indoloylguanidine derivatives | SUMITOMO PHARMA (JP) | 2000-04-12 | — | — | CN | disclosed |
| EP-0937070-A1 | BENZOHETEROCYCLIC DISTAMYCIN DERIVATIVES, PROCESS FOR PREPARING THEM, AND THEIR USE AS ANTITUMOR AND ANTIVIRAL AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 1999-08-25 | — | — | EP | disclosed |
| WO-1998021202-A1 | BENZOHETEROCYCLIC DISTAMYCIN DERIVATIVES, PROCESS FOR PREPARING THEM, AND THEIR USE AS ANTITUMOR AND ANTIVIRAL AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 1998-05-22 | — | — | WO | disclosed |
| CN-1106800-A | Indoloylguanidine derivatives | SUMITOMO PHARMA (JP) | 1995-08-16 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120232052-A1 | ARYL CARBOXAMIDE DERIVATIVES AS TTX-S BLOCKERS | SCN1B, SCN1A, SCN2B | HSD17B10 3409/4885KDM4E 1141/4885ALDH1A1 787/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.