Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | NAMPT | P43490 | 4/20 | 0.46 |
| ▸ | SMO | Q99835 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | APOB | P04114 | 5/20 | 0.43 |
| ▸ | MTTP | P55157 | 4/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6973499 | 0.84 | SMO (0.45) | SMOAPOBMTTPABCB1 | |
| SCHEMBL6964489 | 0.83 | SMO (0.50) | SMOAPOBMTTP | |
| SCHEMBL6969471 | 0.83 | KEAP1 (0.44) | NAMPTAPOBMTTPEPHX2 | |
| SCHEMBL6970162 | 0.82 | NAMPT (0.47) | NAMPTAPOBMTTPEPHX2 | |
| SCHEMBL31018393 | 0.82 | NPC1 (0.49) | NPC1NAMPTRAB9AKMT2APDE4B | |
| SCHEMBL6966377 | 0.82 | APOB (0.44) | NAMPTAPOBMTTPEPHX2 | |
| SCHEMBL6963818 | 0.82 | APOB (0.42) | NAMPTSMOAPOBMTTP | |
| SCHEMBL6968289 | 0.82 | APOB (0.46) | NAMPTAPOBMTTPHTT | |
| SCHEMBL6974662 | 0.82 | EPHX2 (0.45) | NAMPTAPOBMTTPEPHX2 | |
| SCHEMBL6974831 | 0.81 | TMPRSS2 (0.42) | NPC1NAMPTRAB9AKMT2AAPOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832069-B1 | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION | PFIZER (US) | 2003-03-05 | — | — | EP | claimed |