Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 2/20 | 0.50 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | HTR2B | P41595 | 2/20 | 0.45 |
| ▸ | MTTP | P55157 | 4/20 | 0.42 |
| ▸ | GUCY1A1 | Q02108 | 4/20 | 0.42 |
| ▸ | GUCY1B1 | Q02153 | 4/20 | 0.42 |
| ▸ | APOB | P04114 | 3/20 | 0.42 |
| ▸ | SRPK1 | Q96SB4 | 5/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | SRPK2 | P78362 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | SRPK3 | Q9UPE1 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6973499 | 0.93 | SMO (0.45) | SMOHTR2AHTR2CHTR2BMTTP | |
| SCHEMBL6974835 | 0.88 | ABCB1 (0.48) | HTR2CHTR2BMTTPAPOB | |
| SCHEMBL6964482 | 0.87 | MCHR1 (0.43) | SMOHTR2CMTTPAPOB | |
| SCHEMBL6966580 | 0.87 | SCN9A (0.43) | SMOMTTPAPOB | |
| SCHEMBL6969823 | 0.87 | MTTP (0.43) | SMOMTTPAPOBSRPK1 | |
| SCHEMBL6967435 | 0.87 | APOB (0.41) | SMOMTTPAPOB | |
| SCHEMBL6677620 | 0.85 | APOB (0.41) | SMOMTTPAPOB | |
| SCHEMBL6974444 | 0.85 | KDM4E (0.44) | SMOMTTPAPOB | |
| SCHEMBL6965865 | 0.84 | APOB (0.41) | SMOMTTPAPOB | |
| SCHEMBL6974667 | 0.84 | MEN1 (0.49) | MTTPAPOBSRPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832069-B1 | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION | PFIZER (US) | 2003-03-05 | — | — | EP | claimed |